Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series

BACKGROUND: Brucellosis in dogs caused by Brucella suis is an emerging zoonotic disease. OBJECTIVES: To document clinical characteristics, serology, microbiology, and clinical response to treatment in B. suis‐seropositive dogs. ANIMALS: Longitudinal study of 27 privately‐owned dogs. Dogs that tested...

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Autores principales: Kneipp, Catherine C., Deutscher, Ania T., Coilparampil, Ronald, Rose, Anne Marie, Robson, Jennifer, Malik, Richard, Stevenson, Mark A., Wiethoelter, Anke K., Mor, Siobhan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229326/
https://www.ncbi.nlm.nih.gov/pubmed/37158452
http://dx.doi.org/10.1111/jvim.16678
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author Kneipp, Catherine C.
Deutscher, Ania T.
Coilparampil, Ronald
Rose, Anne Marie
Robson, Jennifer
Malik, Richard
Stevenson, Mark A.
Wiethoelter, Anke K.
Mor, Siobhan M.
author_facet Kneipp, Catherine C.
Deutscher, Ania T.
Coilparampil, Ronald
Rose, Anne Marie
Robson, Jennifer
Malik, Richard
Stevenson, Mark A.
Wiethoelter, Anke K.
Mor, Siobhan M.
author_sort Kneipp, Catherine C.
collection PubMed
description BACKGROUND: Brucellosis in dogs caused by Brucella suis is an emerging zoonotic disease. OBJECTIVES: To document clinical characteristics, serology, microbiology, and clinical response to treatment in B. suis‐seropositive dogs. ANIMALS: Longitudinal study of 27 privately‐owned dogs. Dogs that tested positive by serology, culture, or real‐time polymerase chain reaction (qPCR) were included in the study. METHODS: Clinical (physical examination and imaging) and laboratory (serology, hematology, serum biochemistry, and qPCR or culture) assessments were made at baseline and after approximately 3, 6, 12, and 18 months. RESULTS: Dogs were followed for 10 895 dog days, with 17/27 dogs completing the 18‐month follow‐up. Ten dogs had signs consistent with brucellosis before enrollment (n = 4), at baseline (n = 2) or during follow‐up (n = 6), with 2 dogs experiencing relapse of historical signs. Antibody titers persisted for the duration of follow‐up in 15/17 dogs (88%). Radiographic (n = 5) and ultrasound (n = 11) findings, of variable clinical relevance, were observed. Brucella DNA and organisms were detected in 3 dogs, all of which had clinical signs, including in the milk of a bitch around the time of whelping. Brucella DNA was not detected in blood (n = 92 samples), urine (n = 80), saliva (n = 95) or preputial swabs (n = 78) at any time during follow‐up. Six dogs underwent treatment, all of which achieved clinical remission although remission was not reflected by decreasing antibody titers. CONCLUSIONS AND CLINICAL IMPORTANCE: Most dogs with B. suis infections have subclinical infections. Serology is poorly associated with clinical disease. Excretion of organisms appears rare except in whelping bitches. Clinical management using antibiotics with or without surgery is recommended.
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spelling pubmed-102293262023-06-01 Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series Kneipp, Catherine C. Deutscher, Ania T. Coilparampil, Ronald Rose, Anne Marie Robson, Jennifer Malik, Richard Stevenson, Mark A. Wiethoelter, Anke K. Mor, Siobhan M. J Vet Intern Med SMALL ANIMAL BACKGROUND: Brucellosis in dogs caused by Brucella suis is an emerging zoonotic disease. OBJECTIVES: To document clinical characteristics, serology, microbiology, and clinical response to treatment in B. suis‐seropositive dogs. ANIMALS: Longitudinal study of 27 privately‐owned dogs. Dogs that tested positive by serology, culture, or real‐time polymerase chain reaction (qPCR) were included in the study. METHODS: Clinical (physical examination and imaging) and laboratory (serology, hematology, serum biochemistry, and qPCR or culture) assessments were made at baseline and after approximately 3, 6, 12, and 18 months. RESULTS: Dogs were followed for 10 895 dog days, with 17/27 dogs completing the 18‐month follow‐up. Ten dogs had signs consistent with brucellosis before enrollment (n = 4), at baseline (n = 2) or during follow‐up (n = 6), with 2 dogs experiencing relapse of historical signs. Antibody titers persisted for the duration of follow‐up in 15/17 dogs (88%). Radiographic (n = 5) and ultrasound (n = 11) findings, of variable clinical relevance, were observed. Brucella DNA and organisms were detected in 3 dogs, all of which had clinical signs, including in the milk of a bitch around the time of whelping. Brucella DNA was not detected in blood (n = 92 samples), urine (n = 80), saliva (n = 95) or preputial swabs (n = 78) at any time during follow‐up. Six dogs underwent treatment, all of which achieved clinical remission although remission was not reflected by decreasing antibody titers. CONCLUSIONS AND CLINICAL IMPORTANCE: Most dogs with B. suis infections have subclinical infections. Serology is poorly associated with clinical disease. Excretion of organisms appears rare except in whelping bitches. Clinical management using antibiotics with or without surgery is recommended. John Wiley & Sons, Inc. 2023-05-09 /pmc/articles/PMC10229326/ /pubmed/37158452 http://dx.doi.org/10.1111/jvim.16678 Text en © 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Kneipp, Catherine C.
Deutscher, Ania T.
Coilparampil, Ronald
Rose, Anne Marie
Robson, Jennifer
Malik, Richard
Stevenson, Mark A.
Wiethoelter, Anke K.
Mor, Siobhan M.
Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series
title Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series
title_full Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series
title_fullStr Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series
title_full_unstemmed Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series
title_short Clinical investigation and management of Brucella suis seropositive dogs: A longitudinal case series
title_sort clinical investigation and management of brucella suis seropositive dogs: a longitudinal case series
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229326/
https://www.ncbi.nlm.nih.gov/pubmed/37158452
http://dx.doi.org/10.1111/jvim.16678
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