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Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications
Stimuli-responsive synthetic polypeptide-containing block copolymers have received considerable attention in recent years. Especially, unique thermo-induced sol–gel phase transitions were observed for elaborately-designed amphiphilic diblock copolypeptides and a range of poly(ethylene glycol) (PEG)-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229375/ https://www.ncbi.nlm.nih.gov/pubmed/37265604 http://dx.doi.org/10.1093/rb/rbad039 |
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author | Zhao, Dan Rong, Yan Li, Dong He, Chaoliang Chen, Xuesi |
author_facet | Zhao, Dan Rong, Yan Li, Dong He, Chaoliang Chen, Xuesi |
author_sort | Zhao, Dan |
collection | PubMed |
description | Stimuli-responsive synthetic polypeptide-containing block copolymers have received considerable attention in recent years. Especially, unique thermo-induced sol–gel phase transitions were observed for elaborately-designed amphiphilic diblock copolypeptides and a range of poly(ethylene glycol) (PEG)-polypeptide block copolymers. The thermo-induced gelation mechanisms involve the evolution of secondary conformation, enhanced intramolecular interactions, as well as reduced hydration and increased chain entanglement of PEG blocks. The physical parameters, including polymer concentrations, sol–gel transition temperatures and storage moduli, were investigated. The polypeptide hydrogels exhibited good biocompatibility in vitro and in vivo, and displayed biodegradation periods ranging from 1 to 5 weeks. The unique thermo-induced sol–gel phase transitions offer the feasibility of minimal-invasive injection of the precursor aqueous solutions into body, followed by in situ hydrogel formation driven by physiological temperature. These advantages make polypeptide hydrogels interesting candidates for diverse biomedical applications, especially as injectable scaffolds for 3D cell culture and tissue regeneration as well as depots for local drug delivery. This review focuses on recent advances in the design and preparation of injectable, thermo-induced physically crosslinked polypeptide hydrogels. The influence of composition, secondary structure and chirality of polypeptide segments on the physical properties and biodegradation of the hydrogels are emphasized. Moreover, the studies on biomedical applications of the hydrogels are intensively discussed. Finally, the major challenges in the further development of polypeptide hydrogels for practical applications are proposed. |
format | Online Article Text |
id | pubmed-10229375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102293752023-06-01 Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications Zhao, Dan Rong, Yan Li, Dong He, Chaoliang Chen, Xuesi Regen Biomater Review Stimuli-responsive synthetic polypeptide-containing block copolymers have received considerable attention in recent years. Especially, unique thermo-induced sol–gel phase transitions were observed for elaborately-designed amphiphilic diblock copolypeptides and a range of poly(ethylene glycol) (PEG)-polypeptide block copolymers. The thermo-induced gelation mechanisms involve the evolution of secondary conformation, enhanced intramolecular interactions, as well as reduced hydration and increased chain entanglement of PEG blocks. The physical parameters, including polymer concentrations, sol–gel transition temperatures and storage moduli, were investigated. The polypeptide hydrogels exhibited good biocompatibility in vitro and in vivo, and displayed biodegradation periods ranging from 1 to 5 weeks. The unique thermo-induced sol–gel phase transitions offer the feasibility of minimal-invasive injection of the precursor aqueous solutions into body, followed by in situ hydrogel formation driven by physiological temperature. These advantages make polypeptide hydrogels interesting candidates for diverse biomedical applications, especially as injectable scaffolds for 3D cell culture and tissue regeneration as well as depots for local drug delivery. This review focuses on recent advances in the design and preparation of injectable, thermo-induced physically crosslinked polypeptide hydrogels. The influence of composition, secondary structure and chirality of polypeptide segments on the physical properties and biodegradation of the hydrogels are emphasized. Moreover, the studies on biomedical applications of the hydrogels are intensively discussed. Finally, the major challenges in the further development of polypeptide hydrogels for practical applications are proposed. Oxford University Press 2023-04-20 /pmc/articles/PMC10229375/ /pubmed/37265604 http://dx.doi.org/10.1093/rb/rbad039 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Zhao, Dan Rong, Yan Li, Dong He, Chaoliang Chen, Xuesi Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications |
title | Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications |
title_full | Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications |
title_fullStr | Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications |
title_full_unstemmed | Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications |
title_short | Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications |
title_sort | thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229375/ https://www.ncbi.nlm.nih.gov/pubmed/37265604 http://dx.doi.org/10.1093/rb/rbad039 |
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