SIRT2 regulates extracellular vesicle-mediated liver–bone communication

The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans. Liver-specific SIRT2 deficiency inhibits...

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Detalles Bibliográficos
Autores principales: Lin, Longshuai, Guo, Zengya, He, Enjun, Long, Xidai, Wang, Difei, Zhang, Yingting, Guo, Weihong, Wei, Qian, He, Wei, Wu, Wanying, Li, Jingchi, Wo, Lulu, Hong, Dengli, Zheng, Junke, He, Ming, Zhao, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229428/
https://www.ncbi.nlm.nih.gov/pubmed/37188819
http://dx.doi.org/10.1038/s42255-023-00803-0

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