Cargando…
Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial
Diet-induced weight loss is associated with improved beta-cell function in people with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if exercise volume is important for improving beta-cell functio...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229430/ https://www.ncbi.nlm.nih.gov/pubmed/37127822 http://dx.doi.org/10.1038/s42255-023-00799-7 |
_version_ | 1785051252608991232 |
---|---|
author | Legaard, Grit E. Lyngbæk, Mark P. P. Almdal, Thomas P. Karstoft, Kristian Bennetsen, Sebastian L. Feineis, Camilla S. Nielsen, Nina S. Durrer, Cody G. Liebetrau, Benedikte Nystrup, Ulrikke Østergaard, Martin Thomsen, Katja Trinh, Beckey Solomon, Thomas P. J. Van Hall, Gerrit Brønd, Jan Christian Holst, Jens J. Hartmann, Bolette Christensen, Robin Pedersen, Bente K. Ried-Larsen, Mathias |
author_facet | Legaard, Grit E. Lyngbæk, Mark P. P. Almdal, Thomas P. Karstoft, Kristian Bennetsen, Sebastian L. Feineis, Camilla S. Nielsen, Nina S. Durrer, Cody G. Liebetrau, Benedikte Nystrup, Ulrikke Østergaard, Martin Thomsen, Katja Trinh, Beckey Solomon, Thomas P. J. Van Hall, Gerrit Brønd, Jan Christian Holst, Jens J. Hartmann, Bolette Christensen, Robin Pedersen, Bente K. Ried-Larsen, Mathias |
author_sort | Legaard, Grit E. |
collection | PubMed |
description | Diet-induced weight loss is associated with improved beta-cell function in people with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if exercise volume is important for improving beta-cell function in this context. Here, we carried out a four-armed randomized trial with a total of 82 persons (35% females, mean age (s.d.) of 58.2 years (9.8)) with newly diagnosed T2D (<7 years). Participants were randomly allocated to standard care (n = 20), calorie restriction (25% energy reduction; n = 21), calorie restriction and exercise three times per week (n = 20), or calorie restriction and exercise six times per week (n = 21) for 16 weeks. The primary outcome was beta-cell function as indicated by the late-phase disposition index (insulin secretion multiplied by insulin sensitivity) at steady-state hyperglycemia during a hyperglycemic clamp. Secondary outcomes included glucose-stimulated insulin secretion and sensitivity as well as the disposition, insulin sensitivity, and secretion indices derived from a liquid mixed meal tolerance test. We show that the late-phase disposition index during the clamp increases more in all three intervention groups than in standard care (diet control group, 58%; 95% confidence interval (CI), 16 to 116; moderate exercise dose group, 105%; 95% CI, 49 to 182; high exercise dose group, 137%; 95% CI, 73 to 225) and follows a linear dose–response relationship (P > 0.001 for trend). We report three serious adverse events (two in the control group and one in the diet control group), as well as adverse events in two participants in the diet control group, and five participants each in the moderate and high exercise dose groups. Overall, adding an exercise intervention to diet-induced weight loss improves glucose-stimulated beta-cell function in people with newly diagnosed T2D in an exercise dose-dependent manner (NCT03769883). |
format | Online Article Text |
id | pubmed-10229430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102294302023-06-01 Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial Legaard, Grit E. Lyngbæk, Mark P. P. Almdal, Thomas P. Karstoft, Kristian Bennetsen, Sebastian L. Feineis, Camilla S. Nielsen, Nina S. Durrer, Cody G. Liebetrau, Benedikte Nystrup, Ulrikke Østergaard, Martin Thomsen, Katja Trinh, Beckey Solomon, Thomas P. J. Van Hall, Gerrit Brønd, Jan Christian Holst, Jens J. Hartmann, Bolette Christensen, Robin Pedersen, Bente K. Ried-Larsen, Mathias Nat Metab Article Diet-induced weight loss is associated with improved beta-cell function in people with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if exercise volume is important for improving beta-cell function in this context. Here, we carried out a four-armed randomized trial with a total of 82 persons (35% females, mean age (s.d.) of 58.2 years (9.8)) with newly diagnosed T2D (<7 years). Participants were randomly allocated to standard care (n = 20), calorie restriction (25% energy reduction; n = 21), calorie restriction and exercise three times per week (n = 20), or calorie restriction and exercise six times per week (n = 21) for 16 weeks. The primary outcome was beta-cell function as indicated by the late-phase disposition index (insulin secretion multiplied by insulin sensitivity) at steady-state hyperglycemia during a hyperglycemic clamp. Secondary outcomes included glucose-stimulated insulin secretion and sensitivity as well as the disposition, insulin sensitivity, and secretion indices derived from a liquid mixed meal tolerance test. We show that the late-phase disposition index during the clamp increases more in all three intervention groups than in standard care (diet control group, 58%; 95% confidence interval (CI), 16 to 116; moderate exercise dose group, 105%; 95% CI, 49 to 182; high exercise dose group, 137%; 95% CI, 73 to 225) and follows a linear dose–response relationship (P > 0.001 for trend). We report three serious adverse events (two in the control group and one in the diet control group), as well as adverse events in two participants in the diet control group, and five participants each in the moderate and high exercise dose groups. Overall, adding an exercise intervention to diet-induced weight loss improves glucose-stimulated beta-cell function in people with newly diagnosed T2D in an exercise dose-dependent manner (NCT03769883). Nature Publishing Group UK 2023-05-01 2023 /pmc/articles/PMC10229430/ /pubmed/37127822 http://dx.doi.org/10.1038/s42255-023-00799-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Legaard, Grit E. Lyngbæk, Mark P. P. Almdal, Thomas P. Karstoft, Kristian Bennetsen, Sebastian L. Feineis, Camilla S. Nielsen, Nina S. Durrer, Cody G. Liebetrau, Benedikte Nystrup, Ulrikke Østergaard, Martin Thomsen, Katja Trinh, Beckey Solomon, Thomas P. J. Van Hall, Gerrit Brønd, Jan Christian Holst, Jens J. Hartmann, Bolette Christensen, Robin Pedersen, Bente K. Ried-Larsen, Mathias Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial |
title | Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial |
title_full | Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial |
title_fullStr | Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial |
title_full_unstemmed | Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial |
title_short | Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial |
title_sort | effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (dose-ex): a randomized clinical trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229430/ https://www.ncbi.nlm.nih.gov/pubmed/37127822 http://dx.doi.org/10.1038/s42255-023-00799-7 |
work_keys_str_mv | AT legaardgrite effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT lyngbækmarkpp effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT almdalthomasp effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT karstoftkristian effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT bennetsensebastianl effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT feineiscamillas effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT nielsenninas effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT durrercodyg effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT liebetraubenedikte effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT nystrupulrikke effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT østergaardmartin effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT thomsenkatja effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT trinhbeckey effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT solomonthomaspj effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT vanhallgerrit effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT brøndjanchristian effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT holstjensj effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT hartmannbolette effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT christensenrobin effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT pedersenbentek effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial AT riedlarsenmathias effectsofdifferentdosesofexerciseanddietinducedweightlossonbetacellfunctionintype2diabetesdoseexarandomizedclinicaltrial |