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Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase

To overcome chemotherapy resistance, novel strategies sensitizing cancer cells to chemotherapy are required. Here, we screen the lysyl-oxidase (LOX) family to clarify its contribution to chemotherapy resistance in liver cancer. LOXL3 depletion significantly sensitizes liver cancer cells to Oxaliplat...

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Detalles Bibliográficos
Autores principales:	Zhan, Meixiao, Ding, Yufeng, Huang, Shanzhou, Liu, Yuhang, Xiao, Jing, Yu, Hua, Lu, Ligong, Wang, Xiongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229567/ https://www.ncbi.nlm.nih.gov/pubmed/37253718 http://dx.doi.org/10.1038/s41467-023-38753-6

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