B cell-specific knockout of AID protects against atherosclerosis

Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would thus be expected to foster atherosclerosis. Yet, AID also...

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Detalles Bibliográficos
Autores principales: Ebrahimian, Talin, Dierick, France, Ta, Vincent, Kotsiopriftis, Maria, O’Connor Miranda, Jonathan, Mann, Koren K., Orthwein, Alexandre, Lehoux, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229602/
https://www.ncbi.nlm.nih.gov/pubmed/37253865
http://dx.doi.org/10.1038/s41598-023-35980-1

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