Antigen recognition detains CD8(+) T cells at the blood-brain barrier and contributes to its breakdown

Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8(+) T cells are found in MS lesions, and antigen (Ag) presentation at the BBB has been proposed to promote CD8(+) T cell entry int...

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Detalles Bibliográficos
Autores principales: Aydin, Sidar, Pareja, Javier, Schallenberg, Vivianne M., Klopstein, Armelle, Gruber, Thomas, Page, Nicolas, Bouillet, Elisa, Blanchard, Nicolas, Liblau, Roland, Körbelin, Jakob, Schwaninger, Markus, Johnson, Aaron J., Schenk, Mirjam, Deutsch, Urban, Merkler, Doron, Engelhardt, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229608/
https://www.ncbi.nlm.nih.gov/pubmed/37253744
http://dx.doi.org/10.1038/s41467-023-38703-2

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