IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling

Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the development of Th2-driven diseases remains unknown. Using a model of house dust mite (HDM)-induced Th2 cell differentiation and allergic ai...

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Detalles Bibliográficos
Autores principales: Bachus, Holly, McLaughlin, Erin, Lewis, Crystal, Papillion, Amber M., Benveniste, Etty N., Hill, Dave Durell, Rosenberg, Alexander F., Ballesteros-Tato, André, León, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229632/
https://www.ncbi.nlm.nih.gov/pubmed/37046042
http://dx.doi.org/10.1038/s41423-023-01012-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229632/
https://www.ncbi.nlm.nih.gov/pubmed/37046042
http://dx.doi.org/10.1038/s41423-023-01012-1

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