Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation

The NLRP3 inflammasome is a key mediator of the innate immune response to sterile tissue injury and is involved in many chronic and acute diseases. Physically and chemically diverse agents activate the NLRP3 inflammasome. Here, we show that NLRP3 binds non-oxidized and Ox-mtDNA differentially, with...

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Detalles Bibliográficos
Autores principales: Cabral, Angela, Cabral, Julia Elise, Wang, Angelina, Zhang, Yiyang, Liang, Hailin, Nikbakht, Donya, Corona, Leslie, Hoffman, Hal M., McNulty, Reginald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229695/
https://www.ncbi.nlm.nih.gov/pubmed/37253813
http://dx.doi.org/10.1038/s42003-023-04817-y

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