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Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease

Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative illnesses, and yet, no workable treatments have been discovered to prevent or reverse AD. Curcumin (CUR), the major polyphenolic compound of turmeric (Curcuma longa) rhizomes, and Ginkgo biloba extract (GBE) are natural substanc...

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Autores principales: Assi, Abdel-Azim, Farrag, Magda M. Y., Badary, Dalia M., Allam, Essmat A. H., Nicola, Mariam A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229698/
https://www.ncbi.nlm.nih.gov/pubmed/36856916
http://dx.doi.org/10.1007/s10787-023-01164-6
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author Assi, Abdel-Azim
Farrag, Magda M. Y.
Badary, Dalia M.
Allam, Essmat A. H.
Nicola, Mariam A.
author_facet Assi, Abdel-Azim
Farrag, Magda M. Y.
Badary, Dalia M.
Allam, Essmat A. H.
Nicola, Mariam A.
author_sort Assi, Abdel-Azim
collection PubMed
description Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative illnesses, and yet, no workable treatments have been discovered to prevent or reverse AD. Curcumin (CUR), the major polyphenolic compound of turmeric (Curcuma longa) rhizomes, and Ginkgo biloba extract (GBE) are natural substances derived from conventional Chinese herbs that have long been shown to provide therapeutic advantages for AD. The uptake of curcumin into the brain is severely restricted by its low ability to cross the blood–brain barrier (BBB). Meanwhile, GBE has been shown to improve BBB permeability. The present study evaluated the neuroprotective effects and pharmacokinetic profile of curcumin and GBE combination to find out whether GBE can enhance curcumin’s beneficial effects in AD by raising its brain concentration. Results revealed that CUR + GBE achieved significantly higher levels of curcumin in the brain and plasma after 30 min and 1 h of oral administration, compared to curcumin alone, and this was confirmed by reversed phase high-performance liquid chromatography (RP-HPLC). The effect of combined oral treatment, for 28 successive days, on cognitive function and other AD-like alterations was studied in scopolamine-heavy metal mixtures (SCO + HMM) AD model in rats. The combination reversed at least, partially on the learning and memory impairment induced by SCO + HMM. This was associated with a more pronounced inhibitory effect on acetylcholinesterase (AChE), caspase-3, hippocampal amyloid beta (Aβ1-42), and phosphorylated tau protein (p-tau) count, and pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukine-1beta (IL-1β), as compared to the curcumin alone-treated group. Additionally, the combined treatment significantly decreased lipid peroxidation (MDA) and increased levels of reduced glutathione (GSH), when compared with the curcumin alone. These findings support the concept that the combination strategy might be an alternative therapy in the management/prevention of neurological disorders. This study sheds light on a new approach for exploring new phyto-therapies for AD and emphasizes that more research should focus on the synergic effects of herbal drugs in future. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-102296982023-06-01 Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease Assi, Abdel-Azim Farrag, Magda M. Y. Badary, Dalia M. Allam, Essmat A. H. Nicola, Mariam A. Inflammopharmacology Original Article Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative illnesses, and yet, no workable treatments have been discovered to prevent or reverse AD. Curcumin (CUR), the major polyphenolic compound of turmeric (Curcuma longa) rhizomes, and Ginkgo biloba extract (GBE) are natural substances derived from conventional Chinese herbs that have long been shown to provide therapeutic advantages for AD. The uptake of curcumin into the brain is severely restricted by its low ability to cross the blood–brain barrier (BBB). Meanwhile, GBE has been shown to improve BBB permeability. The present study evaluated the neuroprotective effects and pharmacokinetic profile of curcumin and GBE combination to find out whether GBE can enhance curcumin’s beneficial effects in AD by raising its brain concentration. Results revealed that CUR + GBE achieved significantly higher levels of curcumin in the brain and plasma after 30 min and 1 h of oral administration, compared to curcumin alone, and this was confirmed by reversed phase high-performance liquid chromatography (RP-HPLC). The effect of combined oral treatment, for 28 successive days, on cognitive function and other AD-like alterations was studied in scopolamine-heavy metal mixtures (SCO + HMM) AD model in rats. The combination reversed at least, partially on the learning and memory impairment induced by SCO + HMM. This was associated with a more pronounced inhibitory effect on acetylcholinesterase (AChE), caspase-3, hippocampal amyloid beta (Aβ1-42), and phosphorylated tau protein (p-tau) count, and pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukine-1beta (IL-1β), as compared to the curcumin alone-treated group. Additionally, the combined treatment significantly decreased lipid peroxidation (MDA) and increased levels of reduced glutathione (GSH), when compared with the curcumin alone. These findings support the concept that the combination strategy might be an alternative therapy in the management/prevention of neurological disorders. This study sheds light on a new approach for exploring new phyto-therapies for AD and emphasizes that more research should focus on the synergic effects of herbal drugs in future. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2023-03-01 2023 /pmc/articles/PMC10229698/ /pubmed/36856916 http://dx.doi.org/10.1007/s10787-023-01164-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Assi, Abdel-Azim
Farrag, Magda M. Y.
Badary, Dalia M.
Allam, Essmat A. H.
Nicola, Mariam A.
Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease
title Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease
title_full Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease
title_fullStr Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease
title_full_unstemmed Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease
title_short Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease
title_sort protective effects of curcumin and ginkgo biloba extract combination on a new model of alzheimer’s disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229698/
https://www.ncbi.nlm.nih.gov/pubmed/36856916
http://dx.doi.org/10.1007/s10787-023-01164-6
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