Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals

Infertility is a serious medical, economic, and psychological problem in the society. Male factor infertility, due to defective spermatogenesis as a result of a failure in germ cell proliferation and differentiation, appears to be the cause of 25–50% of infertility cases. According to several survey...

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Autores principales: Ismail, Hamdy Y., Hussein, Shaymaa, Shaker, Nora A., Rizk, Hamdy, Wally, Y. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Regenerative Medicine: Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229736/
https://www.ncbi.nlm.nih.gov/pubmed/36602652
http://dx.doi.org/10.1007/s43032-022-01152-1
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author Ismail, Hamdy Y.
Hussein, Shaymaa
Shaker, Nora A.
Rizk, Hamdy
Wally, Y. R.
author_facet Ismail, Hamdy Y.
Hussein, Shaymaa
Shaker, Nora A.
Rizk, Hamdy
Wally, Y. R.
author_sort Ismail, Hamdy Y.
collection PubMed
description Infertility is a serious medical, economic, and psychological problem in the society. Male factor infertility, due to defective spermatogenesis as a result of a failure in germ cell proliferation and differentiation, appears to be the cause of 25–50% of infertility cases. According to several surveys, testicular degeneration can be caused by a variety of physical, chemical, and microbial causes. A stem cell is a non-specialized cell which is characterized by self-renewal by mitotic cell division and able to differentiate to specialized cells for the various tissues of the body. The data were obtained and analyzed from different databases (PubMed, Google Scholar, Egyptian Knowledge Bank, Elsevier, Medline, Embase, ProQuest, and BMC). This review discusses the causes, symptoms, and grades of testicular degeneration and the use of different types of stem cells in regeneration. And its conclusion based on previous researches and trials, MSCs are considered effective therapy for testicular degeneration.
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spelling pubmed-102297362023-06-01 Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals Ismail, Hamdy Y. Hussein, Shaymaa Shaker, Nora A. Rizk, Hamdy Wally, Y. R. Reprod Sci Regenerative Medicine: Review Infertility is a serious medical, economic, and psychological problem in the society. Male factor infertility, due to defective spermatogenesis as a result of a failure in germ cell proliferation and differentiation, appears to be the cause of 25–50% of infertility cases. According to several surveys, testicular degeneration can be caused by a variety of physical, chemical, and microbial causes. A stem cell is a non-specialized cell which is characterized by self-renewal by mitotic cell division and able to differentiate to specialized cells for the various tissues of the body. The data were obtained and analyzed from different databases (PubMed, Google Scholar, Egyptian Knowledge Bank, Elsevier, Medline, Embase, ProQuest, and BMC). This review discusses the causes, symptoms, and grades of testicular degeneration and the use of different types of stem cells in regeneration. And its conclusion based on previous researches and trials, MSCs are considered effective therapy for testicular degeneration. Springer International Publishing 2023-01-05 /pmc/articles/PMC10229736/ /pubmed/36602652 http://dx.doi.org/10.1007/s43032-022-01152-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Regenerative Medicine: Review
Ismail, Hamdy Y.
Hussein, Shaymaa
Shaker, Nora A.
Rizk, Hamdy
Wally, Y. R.
Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals
title Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals
title_full Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals
title_fullStr Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals
title_full_unstemmed Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals
title_short Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals
title_sort stem cell treatment trials for regeneration of testicular tissue in laboratory animals
topic Regenerative Medicine: Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229736/
https://www.ncbi.nlm.nih.gov/pubmed/36602652
http://dx.doi.org/10.1007/s43032-022-01152-1
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