TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN

Hepatic glucose and lipid metabolism disorders promote the development and progression of type 2 diabetes mellitus (T2DM), yet the underlying mechanisms are not fully understood. Here, we identify tripartite motif-containing protein 21 (TRIM21), a class IV TRIM family member, as a pivotal regulator...

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Detalles Bibliográficos
Autores principales: Zhang, Kaini, Yang, Chen, Zhou, Xin, Liang, Jin, Guo, Jianjin, Li, Min, Zhang, Yi, Shao, Shulin, Sun, Peng, Li, Kai, Huang, Jingjing, Chen, Fang, Liang, Xiubin, Su, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229743/
https://www.ncbi.nlm.nih.gov/pubmed/37249651
http://dx.doi.org/10.1007/s00018-023-04820-w

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