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A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease

AIMS: The pathogenesis of disease progression targets for patients with heart failure after acute myocardial infarction was investigated by using plasma proteomics. METHODS: The plasma proteomes of acute myocardial infarction patients with (MI-HF) and without (MI-WHF) heart failure were compared. Ea...

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Autores principales: Liu, Yan, Huang, Da, Li, Zhile, Zhou, LiuFang, Cen, Tuan, Wei, Baomin, Wei, Liuqing, Wu, Hongying, Su, Liye, Sooranna, Suren R., Pan, Xinshou, Huang, ZhaoHe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229768/
https://www.ncbi.nlm.nih.gov/pubmed/37265567
http://dx.doi.org/10.3389/fcvm.2023.1153625
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author Liu, Yan
Huang, Da
Li, Zhile
Zhou, LiuFang
Cen, Tuan
Wei, Baomin
Wei, Liuqing
Wu, Hongying
Su, Liye
Sooranna, Suren R.
Pan, Xinshou
Huang, ZhaoHe
author_facet Liu, Yan
Huang, Da
Li, Zhile
Zhou, LiuFang
Cen, Tuan
Wei, Baomin
Wei, Liuqing
Wu, Hongying
Su, Liye
Sooranna, Suren R.
Pan, Xinshou
Huang, ZhaoHe
author_sort Liu, Yan
collection PubMed
description AIMS: The pathogenesis of disease progression targets for patients with heart failure after acute myocardial infarction was investigated by using plasma proteomics. METHODS: The plasma proteomes of acute myocardial infarction patients with (MI-HF) and without (MI-WHF) heart failure were compared. Each group consisted of 10 patients who were matched for age and sex. The peptides were analyzed by 2-dimensional liquid chromatography coupled to tandem mass spectrometry in a high definition mode. Parallel reaction monitoring (PRM) verified the selected target proteins. RESULTS: We identified and quantified 2,589 and 2,222 proteins, respectively, and found 117 differentially expressed proteins (DEPs) (≥1.5-fold), when the MI-HF and MI-WHF groups were compared. Of these 51 and 66 were significantly up-regulated and down-regulated, respectively. The significant DEPs was subjected to protein–protein interaction network analysis which revealed a central role of the NF-κB signaling pathway in the MI-HF patients. PRM verified that MB, DIAPH1, VNN1, GOT2, SLC4A1, CRP, CKM, SOD3, F7, DLD, PGAM2, GOT1, UBA7 and HYOU1 were 14 proteins which were highly expressed in MI-HF patients. CONCLUSIONS: These findings showed a group of proteins related to the NF-κB signaling pathway in the pathogenesis of patients with poor outcomes after experiencing MI-HF. These proteins may be useful candidate markers for the diagnosis of MI-HF as well as help to elucidate the pathophysiology of this major cause of mortality in older patients.
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spelling pubmed-102297682023-06-01 A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease Liu, Yan Huang, Da Li, Zhile Zhou, LiuFang Cen, Tuan Wei, Baomin Wei, Liuqing Wu, Hongying Su, Liye Sooranna, Suren R. Pan, Xinshou Huang, ZhaoHe Front Cardiovasc Med Cardiovascular Medicine AIMS: The pathogenesis of disease progression targets for patients with heart failure after acute myocardial infarction was investigated by using plasma proteomics. METHODS: The plasma proteomes of acute myocardial infarction patients with (MI-HF) and without (MI-WHF) heart failure were compared. Each group consisted of 10 patients who were matched for age and sex. The peptides were analyzed by 2-dimensional liquid chromatography coupled to tandem mass spectrometry in a high definition mode. Parallel reaction monitoring (PRM) verified the selected target proteins. RESULTS: We identified and quantified 2,589 and 2,222 proteins, respectively, and found 117 differentially expressed proteins (DEPs) (≥1.5-fold), when the MI-HF and MI-WHF groups were compared. Of these 51 and 66 were significantly up-regulated and down-regulated, respectively. The significant DEPs was subjected to protein–protein interaction network analysis which revealed a central role of the NF-κB signaling pathway in the MI-HF patients. PRM verified that MB, DIAPH1, VNN1, GOT2, SLC4A1, CRP, CKM, SOD3, F7, DLD, PGAM2, GOT1, UBA7 and HYOU1 were 14 proteins which were highly expressed in MI-HF patients. CONCLUSIONS: These findings showed a group of proteins related to the NF-κB signaling pathway in the pathogenesis of patients with poor outcomes after experiencing MI-HF. These proteins may be useful candidate markers for the diagnosis of MI-HF as well as help to elucidate the pathophysiology of this major cause of mortality in older patients. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10229768/ /pubmed/37265567 http://dx.doi.org/10.3389/fcvm.2023.1153625 Text en © 2023 Liu, Huang, Li, Zhou, Cen, Wei, Wei, Wu, Su, Sooranna, Pan and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Liu, Yan
Huang, Da
Li, Zhile
Zhou, LiuFang
Cen, Tuan
Wei, Baomin
Wei, Liuqing
Wu, Hongying
Su, Liye
Sooranna, Suren R.
Pan, Xinshou
Huang, ZhaoHe
A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease
title A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease
title_full A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease
title_fullStr A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease
title_full_unstemmed A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease
title_short A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease
title_sort plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229768/
https://www.ncbi.nlm.nih.gov/pubmed/37265567
http://dx.doi.org/10.3389/fcvm.2023.1153625
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