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The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension

OBJECTIVE: Inflammation plays an important role in the pathophysiology of hypertension (HTN). Aggregate index of systemic inflammation (AISI), as a new inflammatory and prognostic marker has emerged recently. Our goal was to determine whether there was a relationship between HTN and AISI. METHODS: W...

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Autores principales: Xiu, Jiaming, Lin, Xueqin, Chen, Qiansheng, Yu, Pei, Lu, Jin, Yang, Yanfang, Chen, Weihua, Bao, Kunming, Wang, Junjie, Zhu, Jinlong, Zhang, Xiaoying, Pan, Yuxiong, Tu, Jiabin, Chen, Kaihong, Chen, Liling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229810/
https://www.ncbi.nlm.nih.gov/pubmed/37265570
http://dx.doi.org/10.3389/fcvm.2023.1163900
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author Xiu, Jiaming
Lin, Xueqin
Chen, Qiansheng
Yu, Pei
Lu, Jin
Yang, Yanfang
Chen, Weihua
Bao, Kunming
Wang, Junjie
Zhu, Jinlong
Zhang, Xiaoying
Pan, Yuxiong
Tu, Jiabin
Chen, Kaihong
Chen, Liling
author_facet Xiu, Jiaming
Lin, Xueqin
Chen, Qiansheng
Yu, Pei
Lu, Jin
Yang, Yanfang
Chen, Weihua
Bao, Kunming
Wang, Junjie
Zhu, Jinlong
Zhang, Xiaoying
Pan, Yuxiong
Tu, Jiabin
Chen, Kaihong
Chen, Liling
author_sort Xiu, Jiaming
collection PubMed
description OBJECTIVE: Inflammation plays an important role in the pathophysiology of hypertension (HTN). Aggregate index of systemic inflammation (AISI), as a new inflammatory and prognostic marker has emerged recently. Our goal was to determine whether there was a relationship between HTN and AISI. METHODS: We analyzed patients with HTN from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The primary end point was cardiovascular mortality. A total of 23,765 participants were divided into four groups according to the AISI quartile level. The association between AISI and cardiovascular mortality in patients with HTN was assessed by survival curves and Cox regression analyses based on NHANES recommended weights. RESULTS: High levels of AISI were significantly associated with cardiovascular mortality in patients with HTN. After full adjustment for confounders, there was no significant difference in the risk of cardiovascular mortality in Q2 and Q3 compared to Q1, while Q4 (HR: 1.91, 95% CI: 1.42–2.58; P < 0.001) had a higher risk of cardiovascular mortality compared to Q1. Results remained similar in subgroup analyses stratified by age (P for interaction = 0.568), gender (P for interaction = 0.059), and obesity (P for interaction = 0.289). CONCLUSIONS: In adults with HTN, elevated AISI levels are significantly associated with an increased risk of cardiovascular mortality and may serve as an early warning parameter for poor prognosis.
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spelling pubmed-102298102023-06-01 The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension Xiu, Jiaming Lin, Xueqin Chen, Qiansheng Yu, Pei Lu, Jin Yang, Yanfang Chen, Weihua Bao, Kunming Wang, Junjie Zhu, Jinlong Zhang, Xiaoying Pan, Yuxiong Tu, Jiabin Chen, Kaihong Chen, Liling Front Cardiovasc Med Cardiovascular Medicine OBJECTIVE: Inflammation plays an important role in the pathophysiology of hypertension (HTN). Aggregate index of systemic inflammation (AISI), as a new inflammatory and prognostic marker has emerged recently. Our goal was to determine whether there was a relationship between HTN and AISI. METHODS: We analyzed patients with HTN from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The primary end point was cardiovascular mortality. A total of 23,765 participants were divided into four groups according to the AISI quartile level. The association between AISI and cardiovascular mortality in patients with HTN was assessed by survival curves and Cox regression analyses based on NHANES recommended weights. RESULTS: High levels of AISI were significantly associated with cardiovascular mortality in patients with HTN. After full adjustment for confounders, there was no significant difference in the risk of cardiovascular mortality in Q2 and Q3 compared to Q1, while Q4 (HR: 1.91, 95% CI: 1.42–2.58; P < 0.001) had a higher risk of cardiovascular mortality compared to Q1. Results remained similar in subgroup analyses stratified by age (P for interaction = 0.568), gender (P for interaction = 0.059), and obesity (P for interaction = 0.289). CONCLUSIONS: In adults with HTN, elevated AISI levels are significantly associated with an increased risk of cardiovascular mortality and may serve as an early warning parameter for poor prognosis. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10229810/ /pubmed/37265570 http://dx.doi.org/10.3389/fcvm.2023.1163900 Text en © 2023 Xiu, Lin, Chen, Yu, Lu, Yang, Chen, Bao, Wang, Zhu, Zhang, Pan, Tu, Chen and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Xiu, Jiaming
Lin, Xueqin
Chen, Qiansheng
Yu, Pei
Lu, Jin
Yang, Yanfang
Chen, Weihua
Bao, Kunming
Wang, Junjie
Zhu, Jinlong
Zhang, Xiaoying
Pan, Yuxiong
Tu, Jiabin
Chen, Kaihong
Chen, Liling
The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension
title The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension
title_full The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension
title_fullStr The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension
title_full_unstemmed The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension
title_short The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension
title_sort aggregate index of systemic inflammation (aisi): a novel predictor for hypertension
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229810/
https://www.ncbi.nlm.nih.gov/pubmed/37265570
http://dx.doi.org/10.3389/fcvm.2023.1163900
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