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The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review

Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby alt...

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Autores principales: Dou, Xiaoke, Chen, Rui, Yang, Juexi, Dai, Maosha, Long, Junhao, Sun, Shujun, Lin, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229812/
https://www.ncbi.nlm.nih.gov/pubmed/37266437
http://dx.doi.org/10.3389/fimmu.2023.1107298
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author Dou, Xiaoke
Chen, Rui
Yang, Juexi
Dai, Maosha
Long, Junhao
Sun, Shujun
Lin, Yun
author_facet Dou, Xiaoke
Chen, Rui
Yang, Juexi
Dai, Maosha
Long, Junhao
Sun, Shujun
Lin, Yun
author_sort Dou, Xiaoke
collection PubMed
description Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby altering the cellular microenvironment and affecting cellular metabolism. By elaborating on the above, we first relate chronic pain to T-cell energy metabolism. Then we summarize the molecules that have affected T-cell energy metabolism in the past five years and divide them into two categories. The first category could play a role in neuropathic pain, and we explain their roles in T-cell function and chronic pain, respectively. The second category has not yet been involved in neuropathic pain, and we focus on how they affect T-cell function by influencing T-cell metabolism. By discussing the above content, this review provides a reference for studying the direct relationship between chronic pain and T-cell metabolism and searching for potential therapeutic targets for the treatment of chronic pain on the level of T-cell energy metabolism.
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spelling pubmed-102298122023-06-01 The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review Dou, Xiaoke Chen, Rui Yang, Juexi Dai, Maosha Long, Junhao Sun, Shujun Lin, Yun Front Immunol Immunology Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby altering the cellular microenvironment and affecting cellular metabolism. By elaborating on the above, we first relate chronic pain to T-cell energy metabolism. Then we summarize the molecules that have affected T-cell energy metabolism in the past five years and divide them into two categories. The first category could play a role in neuropathic pain, and we explain their roles in T-cell function and chronic pain, respectively. The second category has not yet been involved in neuropathic pain, and we focus on how they affect T-cell function by influencing T-cell metabolism. By discussing the above content, this review provides a reference for studying the direct relationship between chronic pain and T-cell metabolism and searching for potential therapeutic targets for the treatment of chronic pain on the level of T-cell energy metabolism. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10229812/ /pubmed/37266437 http://dx.doi.org/10.3389/fimmu.2023.1107298 Text en Copyright © 2023 Dou, Chen, Yang, Dai, Long, Sun and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Dou, Xiaoke
Chen, Rui
Yang, Juexi
Dai, Maosha
Long, Junhao
Sun, Shujun
Lin, Yun
The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
title The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
title_full The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
title_fullStr The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
title_full_unstemmed The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
title_short The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
title_sort potential role of t-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229812/
https://www.ncbi.nlm.nih.gov/pubmed/37266437
http://dx.doi.org/10.3389/fimmu.2023.1107298
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