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The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review
Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby alt...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229812/ https://www.ncbi.nlm.nih.gov/pubmed/37266437 http://dx.doi.org/10.3389/fimmu.2023.1107298 |
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author | Dou, Xiaoke Chen, Rui Yang, Juexi Dai, Maosha Long, Junhao Sun, Shujun Lin, Yun |
author_facet | Dou, Xiaoke Chen, Rui Yang, Juexi Dai, Maosha Long, Junhao Sun, Shujun Lin, Yun |
author_sort | Dou, Xiaoke |
collection | PubMed |
description | Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby altering the cellular microenvironment and affecting cellular metabolism. By elaborating on the above, we first relate chronic pain to T-cell energy metabolism. Then we summarize the molecules that have affected T-cell energy metabolism in the past five years and divide them into two categories. The first category could play a role in neuropathic pain, and we explain their roles in T-cell function and chronic pain, respectively. The second category has not yet been involved in neuropathic pain, and we focus on how they affect T-cell function by influencing T-cell metabolism. By discussing the above content, this review provides a reference for studying the direct relationship between chronic pain and T-cell metabolism and searching for potential therapeutic targets for the treatment of chronic pain on the level of T-cell energy metabolism. |
format | Online Article Text |
id | pubmed-10229812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102298122023-06-01 The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review Dou, Xiaoke Chen, Rui Yang, Juexi Dai, Maosha Long, Junhao Sun, Shujun Lin, Yun Front Immunol Immunology Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby altering the cellular microenvironment and affecting cellular metabolism. By elaborating on the above, we first relate chronic pain to T-cell energy metabolism. Then we summarize the molecules that have affected T-cell energy metabolism in the past five years and divide them into two categories. The first category could play a role in neuropathic pain, and we explain their roles in T-cell function and chronic pain, respectively. The second category has not yet been involved in neuropathic pain, and we focus on how they affect T-cell function by influencing T-cell metabolism. By discussing the above content, this review provides a reference for studying the direct relationship between chronic pain and T-cell metabolism and searching for potential therapeutic targets for the treatment of chronic pain on the level of T-cell energy metabolism. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10229812/ /pubmed/37266437 http://dx.doi.org/10.3389/fimmu.2023.1107298 Text en Copyright © 2023 Dou, Chen, Yang, Dai, Long, Sun and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Dou, Xiaoke Chen, Rui Yang, Juexi Dai, Maosha Long, Junhao Sun, Shujun Lin, Yun The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
title | The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
title_full | The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
title_fullStr | The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
title_full_unstemmed | The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
title_short | The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
title_sort | potential role of t-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229812/ https://www.ncbi.nlm.nih.gov/pubmed/37266437 http://dx.doi.org/10.3389/fimmu.2023.1107298 |
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