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Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential
Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar disorder, autism, and epilepsy. In this artic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229853/ https://www.ncbi.nlm.nih.gov/pubmed/36975001 http://dx.doi.org/10.1093/ijnp/pyad012 |
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author | Dwir, Daniella Khadimallah, Ines Xin, Lijing Rahman, Meredith Du, Fei Öngür, Dost Do, Kim Q |
author_facet | Dwir, Daniella Khadimallah, Ines Xin, Lijing Rahman, Meredith Du, Fei Öngür, Dost Do, Kim Q |
author_sort | Dwir, Daniella |
collection | PubMed |
description | Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar disorder, autism, and epilepsy. In this article we review this literature, its implications for the pathophysiology of SZ, and the potential for development of novel treatment interventions targeting redox and immune signaling. Redox biology and immune signaling in the brain are complex and not fully understood; in addition, there are discrepancies in the literature, especially in patient-oriented studies. Nevertheless, it is clear that abnormalities arise in SZ from an interaction between genetic and environmental factors during sensitive periods of brain development, and these abnormalities disrupt local circuits and long-range connectivity. Interventions that correct these abnormalities may be effective in normalizing brain function in psychotic disorders, especially in early phases of illness. |
format | Online Article Text |
id | pubmed-10229853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102298532023-06-01 Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential Dwir, Daniella Khadimallah, Ines Xin, Lijing Rahman, Meredith Du, Fei Öngür, Dost Do, Kim Q Int J Neuropsychopharmacol Reviews Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar disorder, autism, and epilepsy. In this article we review this literature, its implications for the pathophysiology of SZ, and the potential for development of novel treatment interventions targeting redox and immune signaling. Redox biology and immune signaling in the brain are complex and not fully understood; in addition, there are discrepancies in the literature, especially in patient-oriented studies. Nevertheless, it is clear that abnormalities arise in SZ from an interaction between genetic and environmental factors during sensitive periods of brain development, and these abnormalities disrupt local circuits and long-range connectivity. Interventions that correct these abnormalities may be effective in normalizing brain function in psychotic disorders, especially in early phases of illness. Oxford University Press 2023-03-28 /pmc/articles/PMC10229853/ /pubmed/36975001 http://dx.doi.org/10.1093/ijnp/pyad012 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of CINP. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Reviews Dwir, Daniella Khadimallah, Ines Xin, Lijing Rahman, Meredith Du, Fei Öngür, Dost Do, Kim Q Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential |
title | Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential |
title_full | Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential |
title_fullStr | Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential |
title_full_unstemmed | Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential |
title_short | Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential |
title_sort | redox and immune signaling in schizophrenia: new therapeutic potential |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229853/ https://www.ncbi.nlm.nih.gov/pubmed/36975001 http://dx.doi.org/10.1093/ijnp/pyad012 |
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