Cargando…
Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare life-threatening systemic disease. This study aimed to assess the prognostic value of pretreatment albumin-bilirubin (ALBI). We retrospectively analyzed 168 non-Hodgkin lymphoma-associated secondary hemophagocytic lymphohistiocytosis (NHL...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229876/ https://www.ncbi.nlm.nih.gov/pubmed/37266439 http://dx.doi.org/10.3389/fimmu.2023.1162320 |
_version_ | 1785051379223494656 |
---|---|
author | Cheng, Wanying Duan, Limin Xu, Ji Shu, Yongqian Qiu, Hongxia Yin, Guangli |
author_facet | Cheng, Wanying Duan, Limin Xu, Ji Shu, Yongqian Qiu, Hongxia Yin, Guangli |
author_sort | Cheng, Wanying |
collection | PubMed |
description | Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare life-threatening systemic disease. This study aimed to assess the prognostic value of pretreatment albumin-bilirubin (ALBI). We retrospectively analyzed 168 non-Hodgkin lymphoma-associated secondary hemophagocytic lymphohistiocytosis (NHL-sHLH) patients with hepatic injuries. Multivariable logistic/Cox models and restricted cubic spline models were conducted to evaluate the relationships between the ALBI score and short- and long-term survival. Among 168 adult NHL-sHLH patients, 82 (48.8%) patients died within 30 days after admission, and 144 (85.7%) patients died during the follow-up period. Multivariable logistic/Cox regression model indicated that ALBI grade could be an independent risk factor for predicting the prognosis of patients with 30-day mortality and overall survival (odds ratios [OR](30 days) 5.37, 95% confidence interval 2.41-12.64, P < 0.001; hazard ratios [HR](OS) 1.52, 95% confidence interval 1.06-2.18, P = 0.023), respectively. The restricted cubic spline curve displayed a linear and positive relationship between the ALBI score and risk of mortality (P for nonlinearity =0.503). Furthermore, receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for predicting mortality by integrative analysis of the ALBI score and ferritin was significantly improved compared to the ALBI score (AUC (30 days): 0.820 vs 0.693, P = 0.001; AUC(1 year): 0.754 vs 0.681, P = 0.043) or ferritin (AUC(30 days): 0.820 vs 0.724, P = 0.005; AUC(1 year): 0.754 vs 0.658, P = 0.031) alone. The ALBI score could be a useful indicator of short and long-term survival for NHL-sHLH patients with hepatic injuries. |
format | Online Article Text |
id | pubmed-10229876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102298762023-06-01 Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis Cheng, Wanying Duan, Limin Xu, Ji Shu, Yongqian Qiu, Hongxia Yin, Guangli Front Immunol Immunology Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare life-threatening systemic disease. This study aimed to assess the prognostic value of pretreatment albumin-bilirubin (ALBI). We retrospectively analyzed 168 non-Hodgkin lymphoma-associated secondary hemophagocytic lymphohistiocytosis (NHL-sHLH) patients with hepatic injuries. Multivariable logistic/Cox models and restricted cubic spline models were conducted to evaluate the relationships between the ALBI score and short- and long-term survival. Among 168 adult NHL-sHLH patients, 82 (48.8%) patients died within 30 days after admission, and 144 (85.7%) patients died during the follow-up period. Multivariable logistic/Cox regression model indicated that ALBI grade could be an independent risk factor for predicting the prognosis of patients with 30-day mortality and overall survival (odds ratios [OR](30 days) 5.37, 95% confidence interval 2.41-12.64, P < 0.001; hazard ratios [HR](OS) 1.52, 95% confidence interval 1.06-2.18, P = 0.023), respectively. The restricted cubic spline curve displayed a linear and positive relationship between the ALBI score and risk of mortality (P for nonlinearity =0.503). Furthermore, receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for predicting mortality by integrative analysis of the ALBI score and ferritin was significantly improved compared to the ALBI score (AUC (30 days): 0.820 vs 0.693, P = 0.001; AUC(1 year): 0.754 vs 0.681, P = 0.043) or ferritin (AUC(30 days): 0.820 vs 0.724, P = 0.005; AUC(1 year): 0.754 vs 0.658, P = 0.031) alone. The ALBI score could be a useful indicator of short and long-term survival for NHL-sHLH patients with hepatic injuries. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10229876/ /pubmed/37266439 http://dx.doi.org/10.3389/fimmu.2023.1162320 Text en Copyright © 2023 Cheng, Duan, Xu, Shu, Qiu and Yin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Cheng, Wanying Duan, Limin Xu, Ji Shu, Yongqian Qiu, Hongxia Yin, Guangli Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis |
title | Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis |
title_full | Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis |
title_fullStr | Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis |
title_full_unstemmed | Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis |
title_short | Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis |
title_sort | prognostic value of the albumin-bilirubin score in patients with non-hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229876/ https://www.ncbi.nlm.nih.gov/pubmed/37266439 http://dx.doi.org/10.3389/fimmu.2023.1162320 |
work_keys_str_mv | AT chengwanying prognosticvalueofthealbuminbilirubinscoreinpatientswithnonhodgkinlymphomaassociatedhemophagocyticlymphohistiocytosis AT duanlimin prognosticvalueofthealbuminbilirubinscoreinpatientswithnonhodgkinlymphomaassociatedhemophagocyticlymphohistiocytosis AT xuji prognosticvalueofthealbuminbilirubinscoreinpatientswithnonhodgkinlymphomaassociatedhemophagocyticlymphohistiocytosis AT shuyongqian prognosticvalueofthealbuminbilirubinscoreinpatientswithnonhodgkinlymphomaassociatedhemophagocyticlymphohistiocytosis AT qiuhongxia prognosticvalueofthealbuminbilirubinscoreinpatientswithnonhodgkinlymphomaassociatedhemophagocyticlymphohistiocytosis AT yinguangli prognosticvalueofthealbuminbilirubinscoreinpatientswithnonhodgkinlymphomaassociatedhemophagocyticlymphohistiocytosis |