Shifting the balance: soluble ADAM10 as a potential treatment for Alzheimer's disease

INTRODUCTION: Accumulation of amyloid β in the brain is regarded as a key initiator of Alzheimer's disease pathology. Processing of the amyloid precursor protein (APP) in the amyloidogenic pathway yields neurotoxic amyloid β species. In the non-amyloidogenic pathway, APP is processed by membran...

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Detalles Bibliográficos
Autores principales: Hershkovits, Ayelet Sarah, Gelley, Sivan, Hanna, Rawad, Kleifeld, Oded, Shulman, Avidor, Fishman, Ayelet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229884/
https://www.ncbi.nlm.nih.gov/pubmed/37266401
http://dx.doi.org/10.3389/fnagi.2023.1171123

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