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Role of extrinsic physical cues in cancer progression

The tumor microenvironment (TME) is a complex system composed of many cell types and an extracellular matrix (ECM). During tumorigenesis, cancer cells constantly interact with cellular components, biochemical cues, and the ECM in the TME, all of which make the environment favorable for cancer growth...

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Autores principales: Kim, Ok-Hyeon, Jeon, Tae Jin, Shin, Yong Kyoo, Lee, Hyun Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230013/
https://www.ncbi.nlm.nih.gov/pubmed/37037673
http://dx.doi.org/10.5483/BMBRep.2023-0031
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author Kim, Ok-Hyeon
Jeon, Tae Jin
Shin, Yong Kyoo
Lee, Hyun Jung
author_facet Kim, Ok-Hyeon
Jeon, Tae Jin
Shin, Yong Kyoo
Lee, Hyun Jung
author_sort Kim, Ok-Hyeon
collection PubMed
description The tumor microenvironment (TME) is a complex system composed of many cell types and an extracellular matrix (ECM). During tumorigenesis, cancer cells constantly interact with cellular components, biochemical cues, and the ECM in the TME, all of which make the environment favorable for cancer growth. Emerging evidence has revealed the importance of substrate elasticity and biomechanical forces in tumor progression and metastasis. However, the mechanisms underlying the cell response to mechanical signals—such as extrinsic mechanical forces and forces generated within the TME—are still relatively unknown. Moreover, having a deeper understanding of the mechanisms by which cancer cells sense mechanical forces and transmit signals to the cytoplasm would substantially help develop effective strategies for cancer treatment. This review provides an overview of biomechanical forces in the TME and the intracellular signaling pathways activated by mechanical cues as well as highlights the role of mechanotransductive pathways through mechanosensors that detect the altering biomechanical forces in the TME.
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spelling pubmed-102300132023-06-01 Role of extrinsic physical cues in cancer progression Kim, Ok-Hyeon Jeon, Tae Jin Shin, Yong Kyoo Lee, Hyun Jung BMB Rep Invited Mini Review The tumor microenvironment (TME) is a complex system composed of many cell types and an extracellular matrix (ECM). During tumorigenesis, cancer cells constantly interact with cellular components, biochemical cues, and the ECM in the TME, all of which make the environment favorable for cancer growth. Emerging evidence has revealed the importance of substrate elasticity and biomechanical forces in tumor progression and metastasis. However, the mechanisms underlying the cell response to mechanical signals—such as extrinsic mechanical forces and forces generated within the TME—are still relatively unknown. Moreover, having a deeper understanding of the mechanisms by which cancer cells sense mechanical forces and transmit signals to the cytoplasm would substantially help develop effective strategies for cancer treatment. This review provides an overview of biomechanical forces in the TME and the intracellular signaling pathways activated by mechanical cues as well as highlights the role of mechanotransductive pathways through mechanosensors that detect the altering biomechanical forces in the TME. Korean Society for Biochemistry and Molecular Biology 2023-05-31 2023-04-20 /pmc/articles/PMC10230013/ /pubmed/37037673 http://dx.doi.org/10.5483/BMBRep.2023-0031 Text en Copyright © 2023 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Kim, Ok-Hyeon
Jeon, Tae Jin
Shin, Yong Kyoo
Lee, Hyun Jung
Role of extrinsic physical cues in cancer progression
title Role of extrinsic physical cues in cancer progression
title_full Role of extrinsic physical cues in cancer progression
title_fullStr Role of extrinsic physical cues in cancer progression
title_full_unstemmed Role of extrinsic physical cues in cancer progression
title_short Role of extrinsic physical cues in cancer progression
title_sort role of extrinsic physical cues in cancer progression
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230013/
https://www.ncbi.nlm.nih.gov/pubmed/37037673
http://dx.doi.org/10.5483/BMBRep.2023-0031
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