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Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent
Inflammation contributes to many chronic conditions. It is often associated with circulating pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity. They are often elevated and can serve as markers of inflammation. Previous studies have shown that oxytocin, hCG, gh...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230051/ https://www.ncbi.nlm.nih.gov/pubmed/37266425 http://dx.doi.org/10.3389/fimmu.2023.1148209 |
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author | Mehdi, Syed Faizan Pusapati, Suma Anwar, Muhammad Saad Lohana, Durga Kumar, Parkash Nandula, Savitri Aninditha Nawaz, Fatima Kausar Tracey, Kevin Yang, Huan LeRoith, Derek Brownstein, Michael J. Roth, Jesse |
author_facet | Mehdi, Syed Faizan Pusapati, Suma Anwar, Muhammad Saad Lohana, Durga Kumar, Parkash Nandula, Savitri Aninditha Nawaz, Fatima Kausar Tracey, Kevin Yang, Huan LeRoith, Derek Brownstein, Michael J. Roth, Jesse |
author_sort | Mehdi, Syed Faizan |
collection | PubMed |
description | Inflammation contributes to many chronic conditions. It is often associated with circulating pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity. They are often elevated and can serve as markers of inflammation. Previous studies have shown that oxytocin, hCG, ghrelin, alpha-MSH and ACTH have receptor-mediated anti-inflammatory properties that can rescue cells from damage and death. These peptides have been studied well in the past century. In contrast, GLP-1 and its anti-inflammatory properties have been recognized only recently. GLP-1 has been proven to be a useful adjuvant therapy in type-2 diabetes mellitus, metabolic syndrome, and hyperglycemia. It also lowers HbA1C and protects cells of the cardiovascular and nervous systems by reducing inflammation and apoptosis. In this review we have explored the link between GLP-1, inflammation, and sepsis. |
format | Online Article Text |
id | pubmed-10230051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102300512023-06-01 Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent Mehdi, Syed Faizan Pusapati, Suma Anwar, Muhammad Saad Lohana, Durga Kumar, Parkash Nandula, Savitri Aninditha Nawaz, Fatima Kausar Tracey, Kevin Yang, Huan LeRoith, Derek Brownstein, Michael J. Roth, Jesse Front Immunol Immunology Inflammation contributes to many chronic conditions. It is often associated with circulating pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity. They are often elevated and can serve as markers of inflammation. Previous studies have shown that oxytocin, hCG, ghrelin, alpha-MSH and ACTH have receptor-mediated anti-inflammatory properties that can rescue cells from damage and death. These peptides have been studied well in the past century. In contrast, GLP-1 and its anti-inflammatory properties have been recognized only recently. GLP-1 has been proven to be a useful adjuvant therapy in type-2 diabetes mellitus, metabolic syndrome, and hyperglycemia. It also lowers HbA1C and protects cells of the cardiovascular and nervous systems by reducing inflammation and apoptosis. In this review we have explored the link between GLP-1, inflammation, and sepsis. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10230051/ /pubmed/37266425 http://dx.doi.org/10.3389/fimmu.2023.1148209 Text en Copyright © 2023 Mehdi, Pusapati, Anwar, Lohana, Kumar, Nandula, Nawaz, Tracey, Yang, LeRoith, Brownstein and Roth https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Mehdi, Syed Faizan Pusapati, Suma Anwar, Muhammad Saad Lohana, Durga Kumar, Parkash Nandula, Savitri Aninditha Nawaz, Fatima Kausar Tracey, Kevin Yang, Huan LeRoith, Derek Brownstein, Michael J. Roth, Jesse Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent |
title | Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent |
title_full | Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent |
title_fullStr | Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent |
title_full_unstemmed | Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent |
title_short | Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent |
title_sort | glucagon-like peptide-1: a multi-faceted anti-inflammatory agent |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230051/ https://www.ncbi.nlm.nih.gov/pubmed/37266425 http://dx.doi.org/10.3389/fimmu.2023.1148209 |
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