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Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis

BACKGROUND AND AIM: Sarcopenia and severe vitamin D deficiency are associated with malnutrition and poor prognosis. We investigated the impact of the comorbidity of Child–Pugh (CP) class B/C cirrhosis and the aforementioned complications on the prognosis of patients with cirrhosis. METHODS: We retro...

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Autores principales: Saeki, Chisato, Kanai, Tomoya, Ueda, Kaoru, Nakano, Masanori, Oikawa, Tsunekazu, Torisu, Yuichi, Saruta, Masayuki, Tsubota, Akihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230111/
https://www.ncbi.nlm.nih.gov/pubmed/37265932
http://dx.doi.org/10.1002/jgh3.12900
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author Saeki, Chisato
Kanai, Tomoya
Ueda, Kaoru
Nakano, Masanori
Oikawa, Tsunekazu
Torisu, Yuichi
Saruta, Masayuki
Tsubota, Akihito
author_facet Saeki, Chisato
Kanai, Tomoya
Ueda, Kaoru
Nakano, Masanori
Oikawa, Tsunekazu
Torisu, Yuichi
Saruta, Masayuki
Tsubota, Akihito
author_sort Saeki, Chisato
collection PubMed
description BACKGROUND AND AIM: Sarcopenia and severe vitamin D deficiency are associated with malnutrition and poor prognosis. We investigated the impact of the comorbidity of Child–Pugh (CP) class B/C cirrhosis and the aforementioned complications on the prognosis of patients with cirrhosis. METHODS: We retrospectively evaluated 104 patients with cirrhosis. The cumulative survival rates were compared between patients with and without both or either of these disease conditions: CP class B/C and complications (sarcopenia or severe vitamin D deficiency). Sarcopenia was diagnosed according to the Japan Society of Hepatology criteria. Severe vitamin D deficiency was defined as levels of 25‐hydroxyvitamin D <10 ng/mL in serum. RESULTS: The prevalence of CP class B/C, sarcopenia, and severe vitamin D deficiency was 26.9%, 38.5%, and 24.0%, respectively. Patients with both CP class B/C and sarcopenia had significantly lower survival rates than those without both (hazard ratio [HR] = 6.101; P < 0.001) and with either condition (HR = 6.137; P = 0.001). Similarly, patients with both CP class B/C and severe vitamin D deficiency or with either condition had significantly lower survival rates than those without both conditions (HR = 8.135 or 3.189; P < 0.001 or =0.025, respectively). CP class B/C (HR = 3.354; P = 0.006) and severe vitamin D deficiency (HR = 2.445; P = 0.044) were independent prognostic factors. CONCLUSIONS: The coexistence of CP class B/C and sarcopenia or severe vitamin D deficiency worsened the prognosis of patients with cirrhosis. Nutritional assessments such as sarcopenia and vitamin D status should be considered to better evaluate disease conditions and patient prognosis.
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spelling pubmed-102301112023-06-01 Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis Saeki, Chisato Kanai, Tomoya Ueda, Kaoru Nakano, Masanori Oikawa, Tsunekazu Torisu, Yuichi Saruta, Masayuki Tsubota, Akihito JGH Open Original Articles BACKGROUND AND AIM: Sarcopenia and severe vitamin D deficiency are associated with malnutrition and poor prognosis. We investigated the impact of the comorbidity of Child–Pugh (CP) class B/C cirrhosis and the aforementioned complications on the prognosis of patients with cirrhosis. METHODS: We retrospectively evaluated 104 patients with cirrhosis. The cumulative survival rates were compared between patients with and without both or either of these disease conditions: CP class B/C and complications (sarcopenia or severe vitamin D deficiency). Sarcopenia was diagnosed according to the Japan Society of Hepatology criteria. Severe vitamin D deficiency was defined as levels of 25‐hydroxyvitamin D <10 ng/mL in serum. RESULTS: The prevalence of CP class B/C, sarcopenia, and severe vitamin D deficiency was 26.9%, 38.5%, and 24.0%, respectively. Patients with both CP class B/C and sarcopenia had significantly lower survival rates than those without both (hazard ratio [HR] = 6.101; P < 0.001) and with either condition (HR = 6.137; P = 0.001). Similarly, patients with both CP class B/C and severe vitamin D deficiency or with either condition had significantly lower survival rates than those without both conditions (HR = 8.135 or 3.189; P < 0.001 or =0.025, respectively). CP class B/C (HR = 3.354; P = 0.006) and severe vitamin D deficiency (HR = 2.445; P = 0.044) were independent prognostic factors. CONCLUSIONS: The coexistence of CP class B/C and sarcopenia or severe vitamin D deficiency worsened the prognosis of patients with cirrhosis. Nutritional assessments such as sarcopenia and vitamin D status should be considered to better evaluate disease conditions and patient prognosis. Wiley Publishing Asia Pty Ltd 2023-04-14 /pmc/articles/PMC10230111/ /pubmed/37265932 http://dx.doi.org/10.1002/jgh3.12900 Text en © 2023 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Saeki, Chisato
Kanai, Tomoya
Ueda, Kaoru
Nakano, Masanori
Oikawa, Tsunekazu
Torisu, Yuichi
Saruta, Masayuki
Tsubota, Akihito
Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
title Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
title_full Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
title_fullStr Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
title_full_unstemmed Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
title_short Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
title_sort prognostic significance of sarcopenia and severe vitamin d deficiency in patients with cirrhosis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230111/
https://www.ncbi.nlm.nih.gov/pubmed/37265932
http://dx.doi.org/10.1002/jgh3.12900
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