Cargando…
A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types
BACKGROUND AND AIM: Crohn's disease is an inflammatory condition that affects the gastrointestinal (GI) system. This study aimed to determine the prevalence of upper gastrointestinal Crohn's disease (UGICD) and compare its features to non‐UGICD types. METHODS: We conducted a systematic sea...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230113/ https://www.ncbi.nlm.nih.gov/pubmed/37265933 http://dx.doi.org/10.1002/jgh3.12888 |
_version_ | 1785051447729061888 |
---|---|
author | Tamizifar, Babak Adibi, Peyman Hadipour, Maryam Mohamadi, Vahid |
author_facet | Tamizifar, Babak Adibi, Peyman Hadipour, Maryam Mohamadi, Vahid |
author_sort | Tamizifar, Babak |
collection | PubMed |
description | BACKGROUND AND AIM: Crohn's disease is an inflammatory condition that affects the gastrointestinal (GI) system. This study aimed to determine the prevalence of upper gastrointestinal Crohn's disease (UGICD) and compare its features to non‐UGICD types. METHODS: We conducted a systematic search in the databases PubMed, Web of Science, Scopus, and Google Scholar. The heterogeneity of prevalence estimates was examined, subgroup analyses were carried out, and meta‐analyses were conducted using random‐effects modeling. Prognostic data were qualitatively reviewed and combined. RESULTS: Two‐thousand nine‐hundred and forty studies were retrieved and 32 studies were included in the final analysis. Pooled prevalence of UGICD was 15% (CI: 11–18%) among 14 509 patients. UGICD prevalence did not show any significant increase with time (P = 0.45). The most prevalent (38%, CI: 30–47%) behavior of UGICD was B1 (nonstricturing‐nonpenetrating), while the most common concurrent location was L3 (ileocolon) with a prevalence of 47% (CI: 34–59%). UGICD patients had higher stricturing phenotype (B2) compared to non‐UGICD (0.38 vs 0.30; P = 0.03). There was no significant difference in the prevalence of UGICD between patients classified according to the Montreal or Vienna classification. Stricturing phenotype was more common among Asian patients compared to Western patients (0.44 vs 0.24; P < 0.001). UGICD was a risk factor for surgery and drug therapy and was associated with an aggressive course of the disease and more resections. Pooled prevalence of UGICD was 15%. CONCLUSION: Nonstricturing‐nonpenetrating type was the most prevalent UGICD. UGICD patients had more complications and worse outcomes compared to non‐UGICD patients. |
format | Online Article Text |
id | pubmed-10230113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-102301132023-06-01 A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types Tamizifar, Babak Adibi, Peyman Hadipour, Maryam Mohamadi, Vahid JGH Open Systematic Review BACKGROUND AND AIM: Crohn's disease is an inflammatory condition that affects the gastrointestinal (GI) system. This study aimed to determine the prevalence of upper gastrointestinal Crohn's disease (UGICD) and compare its features to non‐UGICD types. METHODS: We conducted a systematic search in the databases PubMed, Web of Science, Scopus, and Google Scholar. The heterogeneity of prevalence estimates was examined, subgroup analyses were carried out, and meta‐analyses were conducted using random‐effects modeling. Prognostic data were qualitatively reviewed and combined. RESULTS: Two‐thousand nine‐hundred and forty studies were retrieved and 32 studies were included in the final analysis. Pooled prevalence of UGICD was 15% (CI: 11–18%) among 14 509 patients. UGICD prevalence did not show any significant increase with time (P = 0.45). The most prevalent (38%, CI: 30–47%) behavior of UGICD was B1 (nonstricturing‐nonpenetrating), while the most common concurrent location was L3 (ileocolon) with a prevalence of 47% (CI: 34–59%). UGICD patients had higher stricturing phenotype (B2) compared to non‐UGICD (0.38 vs 0.30; P = 0.03). There was no significant difference in the prevalence of UGICD between patients classified according to the Montreal or Vienna classification. Stricturing phenotype was more common among Asian patients compared to Western patients (0.44 vs 0.24; P < 0.001). UGICD was a risk factor for surgery and drug therapy and was associated with an aggressive course of the disease and more resections. Pooled prevalence of UGICD was 15%. CONCLUSION: Nonstricturing‐nonpenetrating type was the most prevalent UGICD. UGICD patients had more complications and worse outcomes compared to non‐UGICD patients. Wiley Publishing Asia Pty Ltd 2023-05-10 /pmc/articles/PMC10230113/ /pubmed/37265933 http://dx.doi.org/10.1002/jgh3.12888 Text en © 2023 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Systematic Review Tamizifar, Babak Adibi, Peyman Hadipour, Maryam Mohamadi, Vahid A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types |
title | A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types |
title_full | A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types |
title_fullStr | A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types |
title_full_unstemmed | A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types |
title_short | A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types |
title_sort | systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (ugi) tract crohn's disease in adults compared to non‐ugi types |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230113/ https://www.ncbi.nlm.nih.gov/pubmed/37265933 http://dx.doi.org/10.1002/jgh3.12888 |
work_keys_str_mv | AT tamizifarbabak asystematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes AT adibipeyman asystematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes AT hadipourmaryam asystematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes AT mohamadivahid asystematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes AT tamizifarbabak systematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes AT adibipeyman systematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes AT hadipourmaryam systematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes AT mohamadivahid systematicreviewandmetaanalysisofprevalenceandclinicalfeaturesofuppergastrointestinalugitractcrohnsdiseaseinadultscomparedtononugitypes |