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Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?
Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain dysfunction. SAE may result in increased mortality, extended length of hospital stay, and long-term cognitive dysfuncti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230136/ https://www.ncbi.nlm.nih.gov/pubmed/37259091 http://dx.doi.org/10.1186/s13054-023-04497-4 |
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author | Bircak-Kuchtova, Barbora Chung, Ha-Yeun Wickel, Jonathan Ehler, Johannes Geis, Christian |
author_facet | Bircak-Kuchtova, Barbora Chung, Ha-Yeun Wickel, Jonathan Ehler, Johannes Geis, Christian |
author_sort | Bircak-Kuchtova, Barbora |
collection | PubMed |
description | Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain dysfunction. SAE may result in increased mortality, extended length of hospital stay, and long-term cognitive dysfunction. The diagnosis of SAE is based on clinical assessments, but a valid biomarker to identify and confirm SAE and to assess SAE severity is missing. Several blood-based biomarkers indicating neuronal injury have been evaluated in sepsis and their potential role as early diagnosis and prognostic markers has been studied. Among those, the neuroaxonal injury marker neurofilament light chain (NfL) was identified to potentially serve as a prognostic biomarker for SAE and to predict long-term cognitive impairment. In this review, we summarize the current knowledge of biomarkers, especially NfL, in SAE and discuss a possible future clinical application considering existing limitations. |
format | Online Article Text |
id | pubmed-10230136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102301362023-06-01 Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? Bircak-Kuchtova, Barbora Chung, Ha-Yeun Wickel, Jonathan Ehler, Johannes Geis, Christian Crit Care Review Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain dysfunction. SAE may result in increased mortality, extended length of hospital stay, and long-term cognitive dysfunction. The diagnosis of SAE is based on clinical assessments, but a valid biomarker to identify and confirm SAE and to assess SAE severity is missing. Several blood-based biomarkers indicating neuronal injury have been evaluated in sepsis and their potential role as early diagnosis and prognostic markers has been studied. Among those, the neuroaxonal injury marker neurofilament light chain (NfL) was identified to potentially serve as a prognostic biomarker for SAE and to predict long-term cognitive impairment. In this review, we summarize the current knowledge of biomarkers, especially NfL, in SAE and discuss a possible future clinical application considering existing limitations. BioMed Central 2023-05-31 /pmc/articles/PMC10230136/ /pubmed/37259091 http://dx.doi.org/10.1186/s13054-023-04497-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Bircak-Kuchtova, Barbora Chung, Ha-Yeun Wickel, Jonathan Ehler, Johannes Geis, Christian Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? |
title | Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? |
title_full | Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? |
title_fullStr | Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? |
title_full_unstemmed | Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? |
title_short | Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? |
title_sort | neurofilament light chains to assess sepsis-associated encephalopathy: are we on the track toward clinical implementation? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230136/ https://www.ncbi.nlm.nih.gov/pubmed/37259091 http://dx.doi.org/10.1186/s13054-023-04497-4 |
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