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Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein

Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ peptides are catabolic products of a typ...

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Detalles Bibliográficos
Autores principales:	Wang, David Tzu-Wei, Tang, Tiffany Y C, Kuo, Chun-Ting, Yu, Yun-Ting, Chen, Eric H L, Lee, Ming-Tao, Tsai, Ruei-Fong, Chen, Hung-Ying, Chiang, Yun-Wei, Chen, Rita P Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230161/ https://www.ncbi.nlm.nih.gov/pubmed/37265546 http://dx.doi.org/10.1093/pnasnexus/pgad162

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