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Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project)
INTRODUCTION: Pregnant women are currently considered a vulnerable population to SARS-CoV-2 infection, with increased risk of severe COVID-19, preterm birth and maternal mortality. There is, however, a paucity of data on the burden of maternal SARS-CoV-2 infection in sub-Saharan countries. The objec...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230341/ https://www.ncbi.nlm.nih.gov/pubmed/37217271 http://dx.doi.org/10.1136/bmjopen-2022-067083 |
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author | Figueroa-Romero, Antía Mendes, Anete Mombo-Ngoma, Ghyslain Mischlinger, Johannes Esen, Meral Vogler, Michael Mazuze, Maura Mombo-Nzamba, Lionel Mbadinga, Benjamin Sanz, Sergi Ramharter, Michael Saute, Francisco Nhampossa, Tacilta Menendez, Clara González, Raquel |
author_facet | Figueroa-Romero, Antía Mendes, Anete Mombo-Ngoma, Ghyslain Mischlinger, Johannes Esen, Meral Vogler, Michael Mazuze, Maura Mombo-Nzamba, Lionel Mbadinga, Benjamin Sanz, Sergi Ramharter, Michael Saute, Francisco Nhampossa, Tacilta Menendez, Clara González, Raquel |
author_sort | Figueroa-Romero, Antía |
collection | PubMed |
description | INTRODUCTION: Pregnant women are currently considered a vulnerable population to SARS-CoV-2 infection, with increased risk of severe COVID-19, preterm birth and maternal mortality. There is, however, a paucity of data on the burden of maternal SARS-CoV-2 infection in sub-Saharan countries. The objective of this study is to determine the prevalence and health effects of maternal SARS-CoV-2 infection in selected sites from Gabon and Mozambique. METHODS AND ANALYSIS: MA-CoV (MAternal CoVid) is an observational, multicentre prospective cohort study where 1000 pregnant women (500 per country) will be enrolled at the antenatal clinic visits. Participants will undergo monthly follow-up at each antenatal care visit, delivery and postpartum visit. The primary study outcome is the prevalence of SARS-CoV-2 infection during pregnancy. The clinical presentation of COVID-19 in pregnancy will also be characterised, and incidence of infection during pregnancy will be evaluated, as well as the risk factors of maternal and neonatal morbidity and mortality associated with SARS-CoV-2 infection and the risk of mother to child transmission of SARS-CoV-2. SARS-CoV-2 infection screening will be performed through PCR diagnosis. ETHICS AND DISSEMINATION: The protocol was reviewed and approved by the Comité National d’Éthique pour la Recherche au Gabon, Comité Nacional de Bioética para Saúde de Moçambique and the Ethics Committee of the Hospital Clinic of Barcelona (Spain). Project results will be presented to all stakeholders and published in open access journals. TRIAL REGISTRATION NUMBER: NCT05303168. |
format | Online Article Text |
id | pubmed-10230341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-102303412023-06-01 Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project) Figueroa-Romero, Antía Mendes, Anete Mombo-Ngoma, Ghyslain Mischlinger, Johannes Esen, Meral Vogler, Michael Mazuze, Maura Mombo-Nzamba, Lionel Mbadinga, Benjamin Sanz, Sergi Ramharter, Michael Saute, Francisco Nhampossa, Tacilta Menendez, Clara González, Raquel BMJ Open Global Health INTRODUCTION: Pregnant women are currently considered a vulnerable population to SARS-CoV-2 infection, with increased risk of severe COVID-19, preterm birth and maternal mortality. There is, however, a paucity of data on the burden of maternal SARS-CoV-2 infection in sub-Saharan countries. The objective of this study is to determine the prevalence and health effects of maternal SARS-CoV-2 infection in selected sites from Gabon and Mozambique. METHODS AND ANALYSIS: MA-CoV (MAternal CoVid) is an observational, multicentre prospective cohort study where 1000 pregnant women (500 per country) will be enrolled at the antenatal clinic visits. Participants will undergo monthly follow-up at each antenatal care visit, delivery and postpartum visit. The primary study outcome is the prevalence of SARS-CoV-2 infection during pregnancy. The clinical presentation of COVID-19 in pregnancy will also be characterised, and incidence of infection during pregnancy will be evaluated, as well as the risk factors of maternal and neonatal morbidity and mortality associated with SARS-CoV-2 infection and the risk of mother to child transmission of SARS-CoV-2. SARS-CoV-2 infection screening will be performed through PCR diagnosis. ETHICS AND DISSEMINATION: The protocol was reviewed and approved by the Comité National d’Éthique pour la Recherche au Gabon, Comité Nacional de Bioética para Saúde de Moçambique and the Ethics Committee of the Hospital Clinic of Barcelona (Spain). Project results will be presented to all stakeholders and published in open access journals. TRIAL REGISTRATION NUMBER: NCT05303168. BMJ Publishing Group 2023-05-22 /pmc/articles/PMC10230341/ /pubmed/37217271 http://dx.doi.org/10.1136/bmjopen-2022-067083 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Global Health Figueroa-Romero, Antía Mendes, Anete Mombo-Ngoma, Ghyslain Mischlinger, Johannes Esen, Meral Vogler, Michael Mazuze, Maura Mombo-Nzamba, Lionel Mbadinga, Benjamin Sanz, Sergi Ramharter, Michael Saute, Francisco Nhampossa, Tacilta Menendez, Clara González, Raquel Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project) |
title | Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project) |
title_full | Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project) |
title_fullStr | Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project) |
title_full_unstemmed | Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project) |
title_short | Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project) |
title_sort | prevalence and impact of sars-cov-2 infection on maternal and infant health in african populations: protocol of a multicentre prospective cohort study (ma-cov project) |
topic | Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230341/ https://www.ncbi.nlm.nih.gov/pubmed/37217271 http://dx.doi.org/10.1136/bmjopen-2022-067083 |
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