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Synthesis of structural analogues of Reversan by ester aminolysis: an access to pyrazolo[1,5-a]pyrimidines from chalcones

Reversan, a multidrug resistance-associated protein (MRP1) inhibitor described more than a decade ago, is a commercial drug (CAS: 313397-13-6) that has a high price and is six to eight times more potent than known drug transporter inhibitors. However, to date, a complete route for synthesizing pyraz...

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Detalles Bibliográficos
Autores principales:	Arias-Gómez, Andres, Macías, Mario A., Portilla, Jaime
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230348/ https://www.ncbi.nlm.nih.gov/pubmed/37266500 http://dx.doi.org/10.1039/d3ra02553e

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