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Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden
The prevalence of multiple myeloma (MM) is increasing in Nordic countries and the rest of the western world. Patients aged ≥75 years at diagnosis constitute an increasing proportion of all MM patients, but are underrepresented in randomized clinical trials. There is an urgent need for studies of the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Fondazione Ferrata Storti
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230423/ https://www.ncbi.nlm.nih.gov/pubmed/36300775 http://dx.doi.org/10.3324/haematol.2021.280424 |
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author | Moore, Kari Lenita Falck Turesson, Ingemar Genell, Anna Klausen, Tobias W. Knut-Bojanowska, Dorota Redder, Louise Sverrisdottir, Ingigerdur Thorsen, Jonathan Vangsted, Annette J. Blimark, Cecilie H. |
author_facet | Moore, Kari Lenita Falck Turesson, Ingemar Genell, Anna Klausen, Tobias W. Knut-Bojanowska, Dorota Redder, Louise Sverrisdottir, Ingigerdur Thorsen, Jonathan Vangsted, Annette J. Blimark, Cecilie H. |
author_sort | Moore, Kari Lenita Falck |
collection | PubMed |
description | The prevalence of multiple myeloma (MM) is increasing in Nordic countries and the rest of the western world. Patients aged ≥75 years at diagnosis constitute an increasing proportion of all MM patients, but are underrepresented in randomized clinical trials. There is an urgent need for studies of the characteristics, treatment and outcome in this cohort. We present data from two nationwide population-based registries of all MM patients diagnosed in Denmark from January 1, 2005 until February 18, 2020, and in Sweden from January 1, 2008 until December 31, 2019, including treatment data for patients diagnosed until 2018 (Denmark) and 2019 (Sweden). In total 4,647 patients were ≥75 years at diagnosis, compared to 7,378 younger patients. Patients ≥75 years, accounting for approximately 40% of all MM patients, are a distinct cohort with more advanced disease at diagnosis, reflected by higher International Staging System (ISS) stage, and a higher proportion have renal failure and anemia. We found a more gradual introduction of modern medications in the older cohort than in the younger, despite simultaneous changes in guidelines. Compared to the cohorts in randomized controlled trials that guide the treatment of non-transplant eligible patients, we found a higher proportion of patients ≥75 years and presenting with ISS III in the real-world populations. Nevertheless, response rates and survival are increasing, indicating that modern treatment regimens are effective and well tolerated also in elderly MM patients in real-world populations. |
format | Online Article Text |
id | pubmed-10230423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Fondazione Ferrata Storti |
record_format | MEDLINE/PubMed |
spelling | pubmed-102304232023-06-01 Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden Moore, Kari Lenita Falck Turesson, Ingemar Genell, Anna Klausen, Tobias W. Knut-Bojanowska, Dorota Redder, Louise Sverrisdottir, Ingigerdur Thorsen, Jonathan Vangsted, Annette J. Blimark, Cecilie H. Haematologica Article - Plasma Cell Disorders The prevalence of multiple myeloma (MM) is increasing in Nordic countries and the rest of the western world. Patients aged ≥75 years at diagnosis constitute an increasing proportion of all MM patients, but are underrepresented in randomized clinical trials. There is an urgent need for studies of the characteristics, treatment and outcome in this cohort. We present data from two nationwide population-based registries of all MM patients diagnosed in Denmark from January 1, 2005 until February 18, 2020, and in Sweden from January 1, 2008 until December 31, 2019, including treatment data for patients diagnosed until 2018 (Denmark) and 2019 (Sweden). In total 4,647 patients were ≥75 years at diagnosis, compared to 7,378 younger patients. Patients ≥75 years, accounting for approximately 40% of all MM patients, are a distinct cohort with more advanced disease at diagnosis, reflected by higher International Staging System (ISS) stage, and a higher proportion have renal failure and anemia. We found a more gradual introduction of modern medications in the older cohort than in the younger, despite simultaneous changes in guidelines. Compared to the cohorts in randomized controlled trials that guide the treatment of non-transplant eligible patients, we found a higher proportion of patients ≥75 years and presenting with ISS III in the real-world populations. Nevertheless, response rates and survival are increasing, indicating that modern treatment regimens are effective and well tolerated also in elderly MM patients in real-world populations. Fondazione Ferrata Storti 2022-10-27 /pmc/articles/PMC10230423/ /pubmed/36300775 http://dx.doi.org/10.3324/haematol.2021.280424 Text en Copyright© 2023 Ferrata Storti Foundation https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article - Plasma Cell Disorders Moore, Kari Lenita Falck Turesson, Ingemar Genell, Anna Klausen, Tobias W. Knut-Bojanowska, Dorota Redder, Louise Sverrisdottir, Ingigerdur Thorsen, Jonathan Vangsted, Annette J. Blimark, Cecilie H. Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden |
title | Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden |
title_full | Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden |
title_fullStr | Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden |
title_full_unstemmed | Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden |
title_short | Improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in Denmark and Sweden |
title_sort | improved survival in myeloma patients–a nationwide registry study of 4,647 patients ≥75 years treated in denmark and sweden |
topic | Article - Plasma Cell Disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230423/ https://www.ncbi.nlm.nih.gov/pubmed/36300775 http://dx.doi.org/10.3324/haematol.2021.280424 |
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