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Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study

BACKGROUND AND AIMS: To evaluate biochemical abnormalities and their association with the outcome of hospitalized coronavirus disease 2019 (COVID‐19) patients at a tertiary referral center in Iran. METHODS: This retrospective study was conducted on COVID‐19 patients who were admitted at tertiary ref...

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Autores principales: Mardani, Sayna, Hakamifard, Atousa, Aghazadeh Sarhangipour, Kouros, Mardani, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230426/
https://www.ncbi.nlm.nih.gov/pubmed/37266063
http://dx.doi.org/10.1002/hsr2.1311
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author Mardani, Sayna
Hakamifard, Atousa
Aghazadeh Sarhangipour, Kouros
Mardani, Masoud
author_facet Mardani, Sayna
Hakamifard, Atousa
Aghazadeh Sarhangipour, Kouros
Mardani, Masoud
author_sort Mardani, Sayna
collection PubMed
description BACKGROUND AND AIMS: To evaluate biochemical abnormalities and their association with the outcome of hospitalized coronavirus disease 2019 (COVID‐19) patients at a tertiary referral center in Iran. METHODS: This retrospective study was conducted on COVID‐19 patients who were admitted at tertiary referral centers in Tehran, Iran, from March 2021 to 2022. Demographic and biochemical laboratory data of the patients including blood sodium, potassium, calcium, and magnesium were collected from patient treatment sheets of severe COVID‐19 patients admitted to a different ward of the hospital. A logistic regression model was fitted to identify the associated parameters with mortality. RESULTS: Four hundred and ninety‐nine patients with COVID‐19, including 287 males (57.5%), who had a mean age of 58.95 ± 16.60 years, were enrolled. Thirty‐eight patients (7.62%) died during hospitalization. The factors we found to be independently associated with an increased risk of in‐hospital death were having comorbidity (mortality of 94.7%, vs. 61% among those without comorbidity; odds ratio, 17.71; 95% confidence interval [CI], 3.81–82.37), hypermagnesemia (34.2%, vs. 26.2% among those with normal magnesium; odds ratio, 9.71; 95% CI, 2.958–31.91), and having a male gender (34.2%, vs. 26.2% among those were female; odds ratio, 9.71; 95% CI, 2.958–31.91) CONCLUSIONS: Hypermagnesemia, having a male gender, and the existence of comorbidity in patients with COVID‐19 is associated with an increase in mortality. Further studies on the pathogenic mechanisms and therapeutic implications need to be done.
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spelling pubmed-102304262023-06-01 Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study Mardani, Sayna Hakamifard, Atousa Aghazadeh Sarhangipour, Kouros Mardani, Masoud Health Sci Rep Original Research BACKGROUND AND AIMS: To evaluate biochemical abnormalities and their association with the outcome of hospitalized coronavirus disease 2019 (COVID‐19) patients at a tertiary referral center in Iran. METHODS: This retrospective study was conducted on COVID‐19 patients who were admitted at tertiary referral centers in Tehran, Iran, from March 2021 to 2022. Demographic and biochemical laboratory data of the patients including blood sodium, potassium, calcium, and magnesium were collected from patient treatment sheets of severe COVID‐19 patients admitted to a different ward of the hospital. A logistic regression model was fitted to identify the associated parameters with mortality. RESULTS: Four hundred and ninety‐nine patients with COVID‐19, including 287 males (57.5%), who had a mean age of 58.95 ± 16.60 years, were enrolled. Thirty‐eight patients (7.62%) died during hospitalization. The factors we found to be independently associated with an increased risk of in‐hospital death were having comorbidity (mortality of 94.7%, vs. 61% among those without comorbidity; odds ratio, 17.71; 95% confidence interval [CI], 3.81–82.37), hypermagnesemia (34.2%, vs. 26.2% among those with normal magnesium; odds ratio, 9.71; 95% CI, 2.958–31.91), and having a male gender (34.2%, vs. 26.2% among those were female; odds ratio, 9.71; 95% CI, 2.958–31.91) CONCLUSIONS: Hypermagnesemia, having a male gender, and the existence of comorbidity in patients with COVID‐19 is associated with an increase in mortality. Further studies on the pathogenic mechanisms and therapeutic implications need to be done. John Wiley and Sons Inc. 2023-05-31 /pmc/articles/PMC10230426/ /pubmed/37266063 http://dx.doi.org/10.1002/hsr2.1311 Text en © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Mardani, Sayna
Hakamifard, Atousa
Aghazadeh Sarhangipour, Kouros
Mardani, Masoud
Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study
title Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study
title_full Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study
title_fullStr Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study
title_full_unstemmed Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study
title_short Electrolyte abnormalities in hospitalized COVID‐19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross‐sectional study
title_sort electrolyte abnormalities in hospitalized covid‐19 patients at tertiary referral centers in tehran: hypermagnesemia as a marker of fatality: a retrospective cross‐sectional study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230426/
https://www.ncbi.nlm.nih.gov/pubmed/37266063
http://dx.doi.org/10.1002/hsr2.1311
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