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“Bone-SASP” in Skeletal Aging
Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230496/ https://www.ncbi.nlm.nih.gov/pubmed/37256358 http://dx.doi.org/10.1007/s00223-023-01100-4 |
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author | Fang, Ching-Lien Liu, Bin Wan, Mei |
author_facet | Fang, Ching-Lien Liu, Bin Wan, Mei |
author_sort | Fang, Ching-Lien |
collection | PubMed |
description | Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead to multiple age-associated disorders by eliciting local and systemic consequences. The skeleton is a highly dynamic organ that changes constantly in shape and composition. Senescent cells in bone and bone marrow produce diverse SASP factors that induce alterations of the skeleton through paracrine effects. Herein, we refer to bone cell-associated SASP as “bone-SASP.” In this review, we describe current knowledge of cellular senescence and SASP, focusing on the role of senescent cells in mediating bone pathologies during natural aging and premature aging syndromes. We also summarize the role of cellular senescence and the bone-SASP in glucocorticoids-induced bone damage. In addition, we discuss the role of bone-SASP in the development of osteoarthritis, highlighting the mechanisms by which bone-SASP drives subchondral bone changes in metabolic syndrome-associated osteoarthritis. |
format | Online Article Text |
id | pubmed-10230496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-102304962023-06-01 “Bone-SASP” in Skeletal Aging Fang, Ching-Lien Liu, Bin Wan, Mei Calcif Tissue Int Review Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead to multiple age-associated disorders by eliciting local and systemic consequences. The skeleton is a highly dynamic organ that changes constantly in shape and composition. Senescent cells in bone and bone marrow produce diverse SASP factors that induce alterations of the skeleton through paracrine effects. Herein, we refer to bone cell-associated SASP as “bone-SASP.” In this review, we describe current knowledge of cellular senescence and SASP, focusing on the role of senescent cells in mediating bone pathologies during natural aging and premature aging syndromes. We also summarize the role of cellular senescence and the bone-SASP in glucocorticoids-induced bone damage. In addition, we discuss the role of bone-SASP in the development of osteoarthritis, highlighting the mechanisms by which bone-SASP drives subchondral bone changes in metabolic syndrome-associated osteoarthritis. Springer US 2023-05-31 2023 /pmc/articles/PMC10230496/ /pubmed/37256358 http://dx.doi.org/10.1007/s00223-023-01100-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Fang, Ching-Lien Liu, Bin Wan, Mei “Bone-SASP” in Skeletal Aging |
title | “Bone-SASP” in Skeletal Aging |
title_full | “Bone-SASP” in Skeletal Aging |
title_fullStr | “Bone-SASP” in Skeletal Aging |
title_full_unstemmed | “Bone-SASP” in Skeletal Aging |
title_short | “Bone-SASP” in Skeletal Aging |
title_sort | “bone-sasp” in skeletal aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230496/ https://www.ncbi.nlm.nih.gov/pubmed/37256358 http://dx.doi.org/10.1007/s00223-023-01100-4 |
work_keys_str_mv | AT fangchinglien bonesaspinskeletalaging AT liubin bonesaspinskeletalaging AT wanmei bonesaspinskeletalaging |