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Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C–C Bond-Forming α-Oxoamine Synthase

[Image: see text] We report a chemo-biocatalytic cascade for the synthesis of substituted pyrroles, driven by the action of an irreversible, thermostable, pyridoxal 5′-phosphate (PLP)-dependent, C–C bond-forming biocatalyst (ThAOS). The ThAOS catalyzes the Claisen-like condensation between various a...

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Detalles Bibliográficos
Autores principales:	Ashley, Ben, Baslé, Arnaud, Sajjad, Mariyah, el Ashram, Ahmed, Kelis, Panayiota, Marles-Wright, Jon, Campopiano, Dominic J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230504/ https://www.ncbi.nlm.nih.gov/pubmed/37266354 http://dx.doi.org/10.1021/acssuschemeng.3c00243

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