Astrocytic pathology in Alpers’ syndrome

Refractory epilepsy is the main neurological manifestation of Alpers’ syndrome, a severe childhood-onset mitochondrial disease caused by bi-allelic pathogenic variants in the mitochondrial DNA (mtDNA) polymerase gamma gene (POLG). The pathophysiological mechanisms underpinning neuronal hyperexcitabi...

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Detalles Bibliográficos
Autores principales: Smith, Laura A, Chen, Chun, Lax, Nichola Z, Taylor, Robert W, Erskine, Daniel, McFarland, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230702/
https://www.ncbi.nlm.nih.gov/pubmed/37259148
http://dx.doi.org/10.1186/s40478-023-01579-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230702/
https://www.ncbi.nlm.nih.gov/pubmed/37259148
http://dx.doi.org/10.1186/s40478-023-01579-w

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