Cargando…

Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries

AIM: Until now, the performance of interferon-γ release assay (IGRA) and Mantoux tests remains unclear in infant tuberculous meningitis (TBM). Therefore, a systematic review is performed to evaluate the sensitivity of IGRA and Mantoux tests for the diagnosis of infant TBM in low and intermediate tub...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yan-Hua, Hou, Jie, He, Yu, Zhang, Yan-An, Wang, Mao-Shui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230717/
https://www.ncbi.nlm.nih.gov/pubmed/37254061
http://dx.doi.org/10.1186/s12879-023-08327-4
_version_ 1785051595203936256
author Yang, Yan-Hua
Hou, Jie
He, Yu
Zhang, Yan-An
Wang, Mao-Shui
author_facet Yang, Yan-Hua
Hou, Jie
He, Yu
Zhang, Yan-An
Wang, Mao-Shui
author_sort Yang, Yan-Hua
collection PubMed
description AIM: Until now, the performance of interferon-γ release assay (IGRA) and Mantoux tests remains unclear in infant tuberculous meningitis (TBM). Therefore, a systematic review is performed to evaluate the sensitivity of IGRA and Mantoux tests for the diagnosis of infant TBM in low and intermediate tuberculosis (TB) burden countries, while following PRISMA. METHODS: Several databases, including PubMed, EBSCO, Embase, Scopus, Web of Science, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials, were searched. Articles describing the results of IGRA or Mantoux tests among infant TBM were included for analysis. Data, such as age, sex, Mantoux test or IGRA, and cerebrospinal fluid (CSF) microbiological examinations (such as acid-fast bacilli (AFB) smear, TB PCR, and TB culture), were extracted from each study. RESULTS: A total of 31 articles were enrolled for further analysis, including 48 cases. The mean age was 9.4 ± 5.8 months and boys accounted for 57.1% of infants (24/42). Mantoux test was positive in 57.4% (27/47) of tested infants and IGRA was positive in 77.8% (7/9) of infants. In addition, among the infants with confirmed TB, 18 (52.9%, 18/34) of them have positive Mantoux responses and 7 (20.0%, 7/35) have positive IGRA results. CONCLUSIONS: In low or intermediate TB burden countries, the Mantoux test has a poor performance for diagnosing TBM among infants, and IGRAs appear to have a moderate sensitivity for the diagnosis of infant TBM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-023-08327-4.
format Online
Article
Text
id pubmed-10230717
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-102307172023-06-01 Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries Yang, Yan-Hua Hou, Jie He, Yu Zhang, Yan-An Wang, Mao-Shui BMC Infect Dis Research AIM: Until now, the performance of interferon-γ release assay (IGRA) and Mantoux tests remains unclear in infant tuberculous meningitis (TBM). Therefore, a systematic review is performed to evaluate the sensitivity of IGRA and Mantoux tests for the diagnosis of infant TBM in low and intermediate tuberculosis (TB) burden countries, while following PRISMA. METHODS: Several databases, including PubMed, EBSCO, Embase, Scopus, Web of Science, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials, were searched. Articles describing the results of IGRA or Mantoux tests among infant TBM were included for analysis. Data, such as age, sex, Mantoux test or IGRA, and cerebrospinal fluid (CSF) microbiological examinations (such as acid-fast bacilli (AFB) smear, TB PCR, and TB culture), were extracted from each study. RESULTS: A total of 31 articles were enrolled for further analysis, including 48 cases. The mean age was 9.4 ± 5.8 months and boys accounted for 57.1% of infants (24/42). Mantoux test was positive in 57.4% (27/47) of tested infants and IGRA was positive in 77.8% (7/9) of infants. In addition, among the infants with confirmed TB, 18 (52.9%, 18/34) of them have positive Mantoux responses and 7 (20.0%, 7/35) have positive IGRA results. CONCLUSIONS: In low or intermediate TB burden countries, the Mantoux test has a poor performance for diagnosing TBM among infants, and IGRAs appear to have a moderate sensitivity for the diagnosis of infant TBM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-023-08327-4. BioMed Central 2023-05-30 /pmc/articles/PMC10230717/ /pubmed/37254061 http://dx.doi.org/10.1186/s12879-023-08327-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yang, Yan-Hua
Hou, Jie
He, Yu
Zhang, Yan-An
Wang, Mao-Shui
Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries
title Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries
title_full Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries
title_fullStr Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries
title_full_unstemmed Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries
title_short Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries
title_sort interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230717/
https://www.ncbi.nlm.nih.gov/pubmed/37254061
http://dx.doi.org/10.1186/s12879-023-08327-4
work_keys_str_mv AT yangyanhua interferongreleaseassayandmantouxresponseininfantswithtuberculousmeningitisinlowandintermediateburdencountries
AT houjie interferongreleaseassayandmantouxresponseininfantswithtuberculousmeningitisinlowandintermediateburdencountries
AT heyu interferongreleaseassayandmantouxresponseininfantswithtuberculousmeningitisinlowandintermediateburdencountries
AT zhangyanan interferongreleaseassayandmantouxresponseininfantswithtuberculousmeningitisinlowandintermediateburdencountries
AT wangmaoshui interferongreleaseassayandmantouxresponseininfantswithtuberculousmeningitisinlowandintermediateburdencountries