Cargando…

Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits

Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have received much attention for the improvement of obesity and metabolic disorders. However, even though the thermogenic and metabolic potential exists early after transplantation, the whitening o...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Tao, Chen, Xu, Jiang, Shenglu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230949/
https://www.ncbi.nlm.nih.gov/pubmed/37265692
http://dx.doi.org/10.3389/fendo.2023.1191278
_version_ 1785051646863081472
author Zhu, Tao
Chen, Xu
Jiang, Shenglu
author_facet Zhu, Tao
Chen, Xu
Jiang, Shenglu
author_sort Zhu, Tao
collection PubMed
description Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have received much attention for the improvement of obesity and metabolic disorders. However, even though the thermogenic and metabolic potential exists early after transplantation, the whitening of the brown fat graft occurs with metabolic function significantly impaired. In this review, specific experiment designs, graft outcomes, and metabolic benefits for the transplantation of BAT or engineered cells will be discussed. The current advancements will offer guidance to further investigation, and the obstacles appearing in previous studies will require innovation of BAT transplantation methods.
format Online
Article
Text
id pubmed-10230949
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102309492023-06-01 Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits Zhu, Tao Chen, Xu Jiang, Shenglu Front Endocrinol (Lausanne) Endocrinology Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have received much attention for the improvement of obesity and metabolic disorders. However, even though the thermogenic and metabolic potential exists early after transplantation, the whitening of the brown fat graft occurs with metabolic function significantly impaired. In this review, specific experiment designs, graft outcomes, and metabolic benefits for the transplantation of BAT or engineered cells will be discussed. The current advancements will offer guidance to further investigation, and the obstacles appearing in previous studies will require innovation of BAT transplantation methods. Frontiers Media S.A. 2023-05-16 /pmc/articles/PMC10230949/ /pubmed/37265692 http://dx.doi.org/10.3389/fendo.2023.1191278 Text en Copyright © 2023 Zhu, Chen and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhu, Tao
Chen, Xu
Jiang, Shenglu
Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
title Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
title_full Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
title_fullStr Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
title_full_unstemmed Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
title_short Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
title_sort progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230949/
https://www.ncbi.nlm.nih.gov/pubmed/37265692
http://dx.doi.org/10.3389/fendo.2023.1191278
work_keys_str_mv AT zhutao progressandobstaclesintransplantationofbrownadiposetissueorengineeredcellswiththermogenicpotentialformetabolicbenefits
AT chenxu progressandobstaclesintransplantationofbrownadiposetissueorengineeredcellswiththermogenicpotentialformetabolicbenefits
AT jiangshenglu progressandobstaclesintransplantationofbrownadiposetissueorengineeredcellswiththermogenicpotentialformetabolicbenefits