Cargando…
Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have received much attention for the improvement of obesity and metabolic disorders. However, even though the thermogenic and metabolic potential exists early after transplantation, the whitening o...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230949/ https://www.ncbi.nlm.nih.gov/pubmed/37265692 http://dx.doi.org/10.3389/fendo.2023.1191278 |
_version_ | 1785051646863081472 |
---|---|
author | Zhu, Tao Chen, Xu Jiang, Shenglu |
author_facet | Zhu, Tao Chen, Xu Jiang, Shenglu |
author_sort | Zhu, Tao |
collection | PubMed |
description | Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have received much attention for the improvement of obesity and metabolic disorders. However, even though the thermogenic and metabolic potential exists early after transplantation, the whitening of the brown fat graft occurs with metabolic function significantly impaired. In this review, specific experiment designs, graft outcomes, and metabolic benefits for the transplantation of BAT or engineered cells will be discussed. The current advancements will offer guidance to further investigation, and the obstacles appearing in previous studies will require innovation of BAT transplantation methods. |
format | Online Article Text |
id | pubmed-10230949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102309492023-06-01 Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits Zhu, Tao Chen, Xu Jiang, Shenglu Front Endocrinol (Lausanne) Endocrinology Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have received much attention for the improvement of obesity and metabolic disorders. However, even though the thermogenic and metabolic potential exists early after transplantation, the whitening of the brown fat graft occurs with metabolic function significantly impaired. In this review, specific experiment designs, graft outcomes, and metabolic benefits for the transplantation of BAT or engineered cells will be discussed. The current advancements will offer guidance to further investigation, and the obstacles appearing in previous studies will require innovation of BAT transplantation methods. Frontiers Media S.A. 2023-05-16 /pmc/articles/PMC10230949/ /pubmed/37265692 http://dx.doi.org/10.3389/fendo.2023.1191278 Text en Copyright © 2023 Zhu, Chen and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Zhu, Tao Chen, Xu Jiang, Shenglu Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits |
title | Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits |
title_full | Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits |
title_fullStr | Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits |
title_full_unstemmed | Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits |
title_short | Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits |
title_sort | progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230949/ https://www.ncbi.nlm.nih.gov/pubmed/37265692 http://dx.doi.org/10.3389/fendo.2023.1191278 |
work_keys_str_mv | AT zhutao progressandobstaclesintransplantationofbrownadiposetissueorengineeredcellswiththermogenicpotentialformetabolicbenefits AT chenxu progressandobstaclesintransplantationofbrownadiposetissueorengineeredcellswiththermogenicpotentialformetabolicbenefits AT jiangshenglu progressandobstaclesintransplantationofbrownadiposetissueorengineeredcellswiththermogenicpotentialformetabolicbenefits |