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Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer

OBJECTIVE: To explore the correlation between ultrasound images and molecular typing of invasive breast cancer, so as to analyze the predictive value of preoperative ultrasound for invasive breast cancer. METHODS: 302 invasive breast cancer patients were enrolled in Heping Hospital affiliated to Cha...

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Autores principales: Pan, Qiao-Hong, Zhang, Zheng-Pin, Yan, Liu-Yi, Jia, Ning-Rui, Ren, Xin-Yu, Wu, Bei-Ke, Hao, Yu-Bing, Li, Zhi-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230953/
https://www.ncbi.nlm.nih.gov/pubmed/37265799
http://dx.doi.org/10.3389/fonc.2023.1110796
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author Pan, Qiao-Hong
Zhang, Zheng-Pin
Yan, Liu-Yi
Jia, Ning-Rui
Ren, Xin-Yu
Wu, Bei-Ke
Hao, Yu-Bing
Li, Zhi-Fang
author_facet Pan, Qiao-Hong
Zhang, Zheng-Pin
Yan, Liu-Yi
Jia, Ning-Rui
Ren, Xin-Yu
Wu, Bei-Ke
Hao, Yu-Bing
Li, Zhi-Fang
author_sort Pan, Qiao-Hong
collection PubMed
description OBJECTIVE: To explore the correlation between ultrasound images and molecular typing of invasive breast cancer, so as to analyze the predictive value of preoperative ultrasound for invasive breast cancer. METHODS: 302 invasive breast cancer patients were enrolled in Heping Hospital affiliated to Changzhi Medical College in Shanxi, China during 2020 to 2022. All patients accepted ultrasonic and pathological examination, and all pathological tissues received molecular typing with immunohistochemical (IHC) staining. The relevance between different molecular typings and ultrasonic image, pathology were evaluated. RESULTS: Univariate analysis: among the four molecular typings, there were significant differences in tumor size, shape, margin, lymph node and histological grade (P<0.05). 1. Size: Luminal A tumor was smaller (69.4%), Basal -like type tumors are mostly larger (60.9%); 2. Shape: Basal-like type is more likely to show regular shape (45.7%); 3. Margin: Luminal A and Luminal B mostly are not circumscribed (79.6%, 74.8%), Basal -like type shows circumscribed(52.2%); 4. Lymph nodes: Luminal A type tends to be normal (87.8%), Luminal B type,Her-2+ type and Basal-like type tend to be abnormal (35.6%,36.4% and 39.1%). There was no significant difference in mass orientation, echo pattern, rear echo and calcification (P>0.05). Multivariate analysis: Basal-like breast cancer mostly showed regular shape, circumscribed margin and abnormal lymph nodes (P<0.05). CONCLUSION: There are differences in the ultrasound manifestations of different molecular typings of breast cancer, and ultrasound features can be used as a potential imaging index to provide important information for the precise diagnosis and treatment of breast cancer.
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spelling pubmed-102309532023-06-01 Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer Pan, Qiao-Hong Zhang, Zheng-Pin Yan, Liu-Yi Jia, Ning-Rui Ren, Xin-Yu Wu, Bei-Ke Hao, Yu-Bing Li, Zhi-Fang Front Oncol Oncology OBJECTIVE: To explore the correlation between ultrasound images and molecular typing of invasive breast cancer, so as to analyze the predictive value of preoperative ultrasound for invasive breast cancer. METHODS: 302 invasive breast cancer patients were enrolled in Heping Hospital affiliated to Changzhi Medical College in Shanxi, China during 2020 to 2022. All patients accepted ultrasonic and pathological examination, and all pathological tissues received molecular typing with immunohistochemical (IHC) staining. The relevance between different molecular typings and ultrasonic image, pathology were evaluated. RESULTS: Univariate analysis: among the four molecular typings, there were significant differences in tumor size, shape, margin, lymph node and histological grade (P<0.05). 1. Size: Luminal A tumor was smaller (69.4%), Basal -like type tumors are mostly larger (60.9%); 2. Shape: Basal-like type is more likely to show regular shape (45.7%); 3. Margin: Luminal A and Luminal B mostly are not circumscribed (79.6%, 74.8%), Basal -like type shows circumscribed(52.2%); 4. Lymph nodes: Luminal A type tends to be normal (87.8%), Luminal B type,Her-2+ type and Basal-like type tend to be abnormal (35.6%,36.4% and 39.1%). There was no significant difference in mass orientation, echo pattern, rear echo and calcification (P>0.05). Multivariate analysis: Basal-like breast cancer mostly showed regular shape, circumscribed margin and abnormal lymph nodes (P<0.05). CONCLUSION: There are differences in the ultrasound manifestations of different molecular typings of breast cancer, and ultrasound features can be used as a potential imaging index to provide important information for the precise diagnosis and treatment of breast cancer. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10230953/ /pubmed/37265799 http://dx.doi.org/10.3389/fonc.2023.1110796 Text en Copyright © 2023 Pan, Zhang, Yan, Jia, Ren, Wu, Hao and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Pan, Qiao-Hong
Zhang, Zheng-Pin
Yan, Liu-Yi
Jia, Ning-Rui
Ren, Xin-Yu
Wu, Bei-Ke
Hao, Yu-Bing
Li, Zhi-Fang
Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer
title Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer
title_full Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer
title_fullStr Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer
title_full_unstemmed Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer
title_short Association between ultrasound BI-RADS signs and molecular typing of invasive breast cancer
title_sort association between ultrasound bi-rads signs and molecular typing of invasive breast cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230953/
https://www.ncbi.nlm.nih.gov/pubmed/37265799
http://dx.doi.org/10.3389/fonc.2023.1110796
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