Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers

INTRODUCTION: This is the first efficacy study of an oral live attenuated vaccine against Salmonella Paratyphi A using a human challenge model of paratyphoid infection. S. Paratyphi A is responsible for 3.3 million cases of enteric fever every year, with over 19 000 deaths. Although improvements to...

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Detalles Bibliográficos
Autores principales: McCann, Naina, Emary, Katherine, Singh, Nisha, Mclean, Florence, Camara, Susana, Jones, Elizabeth, Kim, Young Chan, Liu, Xinxue, Greenland, Melanie, Conlin, Kerry, Hill, Jennifer, Verheul, Marije, Robinson, Hannah, Angus, Brian, Ramasamy, Maheshi N, Levine, Myron M, Pollard, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Infectious Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230971/
https://www.ncbi.nlm.nih.gov/pubmed/37225278
http://dx.doi.org/10.1136/bmjopen-2022-068966

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