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Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia

BACKGROUND: Type I interferons (IFN-Is), secreted by hematopoietic cells, drive immune surveillance of solid tumors. However, the mechanisms of suppression of IFN-I-driven immune responses in hematopoietic malignancies including B-cell acute lymphoblastic leukemia (B-ALL) are unknown. METHODS: Using...

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Detalles Bibliográficos
Autores principales:	Kumar, Anil, Taghi Khani, Adeleh, Duault, Caroline, Aramburo, Soraya, Sanchez Ortiz, Ashly, Lee, Sung June, Chan, Anthony, McDonald, Tinisha, Huang, Min, Lacayo, Norman J., Sakamoto, Kathleen M., Yu, Jianhua, Hurtz, Christian, Carroll, Martin, Tasian, Sarah K., Ghoda, Lucy, Marcucci, Guido, Gu, Zhaohui, Rosen, Steven T., Armenian, Saro, Izraeli, Shai, Chen, Chun-Wei, Caligiuri, Michael A., Forman, Stephen J., Maecker, Holden T., Swaminathan, Srividya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231005/ https://www.ncbi.nlm.nih.gov/pubmed/37217248 http://dx.doi.org/10.1136/jitc-2022-006649

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