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Dendritic cell therapy augments antitumor immunity triggered by CDK4/6 inhibition and immune checkpoint blockade by unleashing systemic CD4 T-cell responses
BACKGROUND: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are a mainstay treatment for hormone receptor-positive breast cancer. While their principal mechanism is inhibition of cancer cell proliferation, preclinical and clinical evidence suggests that CDK4/6i can a...
Autores principales: | Kumar, Amrendra, Ramani, Vijay, Bharti, Vijaya, de Lima Bellan, Daniel, Saleh, Nabil, Uzhachenko, Roman, Shen, Chengli, Arteaga, Carlos, Richmond, Ann, Reddy, Sangeetha M, Vilgelm, Anna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231009/ https://www.ncbi.nlm.nih.gov/pubmed/37230537 http://dx.doi.org/10.1136/jitc-2022-006019 |
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