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Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets

Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs) (such as PD-1 and CTLA4) can limit T cell receptor (TCR) signal propagation in T cells. Antibody-based blocking of immune checkpoints (immune...

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Detalles Bibliográficos
Autores principales:	Laletin, Vladimir, Bernard, Pierre-Louis, Costa da Silva, Cathy, Guittard, Geoffrey, Nunes, Jacques A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231026/ https://www.ncbi.nlm.nih.gov/pubmed/37217244 http://dx.doi.org/10.1136/jitc-2022-005845

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