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Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus

ANP32 proteins, which act as influenza polymerase cofactors, vary between birds and mammals. In mammals, ANP32A and ANP32B have been reported to serve essential but redundant roles to support influenza polymerase activity. The well-known mammalian adaptation PB2-E627K enables influenza polymerase to...

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Detalles Bibliográficos
Autores principales: Peacock, Thomas P., Sheppard, Carol M., Lister, Margaret G., Staller, Ecco, Frise, Rebecca, Swann, Olivia C., Goldhill, Daniel H., Long, Jason S., Barclay, Wendy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231198/
https://www.ncbi.nlm.nih.gov/pubmed/37074204
http://dx.doi.org/10.1128/jvi.00213-23