Cargando…

Single-Virus Fusion Measurements Reveal Multiple Mechanistically Equivalent Pathways for SARS-CoV-2 Entry

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to cell surface receptors and is activated for membrane fusion and cell entry via proteolytic cleavage. Phenomenological data have shown that SARS-CoV-2 can be activated for entry at either the cell surface or in endosomes, but the r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sengar, Anjali, Cervantes, Marcos, Bondalapati, Sai T., Hess, Tobin, Kasson, Peter M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231210/ https://www.ncbi.nlm.nih.gov/pubmed/37133381 http://dx.doi.org/10.1128/jvi.01992-22

Ejemplares similares

Spike Glycoprotein and Host Cell Determinants of SARS-CoV-2 Entry and Cytopathic Effects
por: Nguyen, Hanh T., et al.
Publicado: (2021)

LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2
por: Zhao, Xuesen, et al.
Publicado: (2020)

The ACE2 receptor accelerates but is not biochemically required for SARS-CoV-2 membrane fusion
por: Cervantes, Marcos, et al.
Publicado: (2023)

Elucidating coronavirus fusion mechanisms
por: Hess, Tobin, et al.
Publicado: (2023)

SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation
por: Hörnich, Bojan F., et al.
Publicado: (2021)

Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry
por: Choi, Sheyne S. A., et al.
Publicado: (2022)

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease
por: Kreutzberger, Alex J. B., et al.
Publicado: (2021)

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling
por: Frolova, Elena I., et al.
Publicado: (2022)

SARS-CoV-2 Spike Furin Cleavage Site and S2′ Basic Residues Modulate the Entry Process in a Host Cell-Dependent Manner
por: Lavie, Muriel, et al.
Publicado: (2022)

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
por: Kettunen, Pinja, et al.
Publicado: (2023)

Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition
por: Navaratnarajah, Chanakha K., et al.
Publicado: (2021)

Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV
por: Lokugamage, Kumari G., et al.
Publicado: (2020)

Single-Particle Detection of Transcription following Rotavirus Entry
por: Salgado, Eric N., et al.
Publicado: (2017)

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry
por: Wan, Yushun, et al.
Publicado: (2020)

Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus
por: Wang, Xinxin, et al.
Publicado: (2023)

N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism
por: Hayashi, Yasuhiro, et al.
Publicado: (2021)

Visualization of Calcium Ion Loss from Rotavirus during Cell Entry
por: Salgado, Eric N., et al.
Publicado: (2018)

Efficient clathrin-mediated entry of enteric adenoviruses in human duodenal cells
por: Becker, Miriam, et al.
Publicado: (2023)

SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and Interferon Antagonism than Its SARS-CoV Ortholog
por: Chen, Jiyao, et al.
Publicado: (2022)

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry
por: Haga, Ismar R., et al.
Publicado: (2014)

Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry
por: Smith, Timothy J., et al.
Publicado: (2023)

Bub1 Facilitates Virus Entry through Endocytosis in a Model of Drosophila Pathogenesis
por: Yang, Shuo, et al.
Publicado: (2018)

Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry
por: Liu, Yongmei, et al.
Publicado: (2023)

Characterization of Entry Pathways, Species-Specific Angiotensin-Converting Enzyme 2 Residues Determining Entry, and Antibody Neutralization Evasion of Omicron BA.1, BA.1.1, BA.2, and BA.3 Variants
por: Neerukonda, Sabari Nath, et al.
Publicado: (2022)

Mapping the pH Sensors Critical for Host Cell Entry by a Complex Nonenveloped Virus
por: Wu, Weining, et al.
Publicado: (2019)

Sialic Acid Binding Sites in VP2 of Bluetongue Virus and Their Use during Virus Entry
por: Wu, Weining, et al.
Publicado: (2022)

SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist
por: Li, Aixin, et al.
Publicado: (2021)

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
por: Essalmani, Rachid, et al.
Publicado: (2022)

Generation and Characterization of Recombinant SARS-CoV-2 Expressing Reporter Genes
por: Chiem, Kevin, et al.
Publicado: (2021)

SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction
por: Deinhardt-Emmer, Stefanie, et al.
Publicado: (2021)

Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection
por: Ariumi, Yasuo
Publicado: (2022)

SARS-CoV-2 and Three Related Coronaviruses Utilize Multiple ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-Ig
por: Li, Yujun, et al.
Publicado: (2020)

The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry
por: Wang, Guangwen, et al.
Publicado: (2020)

The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication
por: Nilsson-Payant, Benjamin E., et al.
Publicado: (2021)

Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells
por: Aicher, Sophie-Marie, et al.
Publicado: (2022)

Mucosal Gene Expression in Response to SARS-CoV-2 Is Associated with Viral Load
por: Rajagopala, Seesandra V., et al.
Publicado: (2023)

Filoviruses Use the HOPS Complex and UVRAG To Traffic to Niemann-Pick C1 Compartments during Viral Entry
por: Bo, Yuxia, et al.
Publicado: (2020)

GB Virus B and Hepatitis C Virus, Distantly Related Hepaciviruses, Share an Entry Factor, Claudin-1
por: Toon, Kamilla, et al.
Publicado: (2023)

Direct Activation of Endothelial Cells by SARS-CoV-2 Nucleocapsid Protein Is Blocked by Simvastatin
por: Qian, Yisong, et al.
Publicado: (2021)

The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles
por: Du, Shouwen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ul4gqgij3ki0tn0npvgnhtdkrn