Enantioselective total syntheses of six natural and two proposed meroterpenoids from Psoralea corylifolia

The first enantioselective total syntheses of six natural and two proposed meroterpenoids isolated from Psoralea corylifolia have been achieved in 7–9 steps from 2-methylcyclohexanone. The current synthetic approaches feature a high level of synthetic flexibility, stereodivergent fashion and short s...

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Detalles Bibliográficos
Autores principales: Chen, Xiao-Wei, Hou, Zi-Chao, Chen, Chi, Zhang, Ling-Hui, Chen, Meng-En, Zhang, Fu-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231314/
https://www.ncbi.nlm.nih.gov/pubmed/37265714
http://dx.doi.org/10.1039/d3sc00582h
Descripción
Sumario:The first enantioselective total syntheses of six natural and two proposed meroterpenoids isolated from Psoralea corylifolia have been achieved in 7–9 steps from 2-methylcyclohexanone. The current synthetic approaches feature a high level of synthetic flexibility, stereodivergent fashion and short synthetic route, thereby providing a potential platform for the preparation of numerous this-type meroterpenoids and their pseudo-natural products.

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