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Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains

SHP2 plays an important role in regulating cellular processes, and its pathogenic mutations cause developmental disorders and are linked to cancer. SHP2 is a multidomain protein, comprising two SH2 domains arranged in tandem, a catalytic PTP domain, and a disordered C-terminal tail. SHP2 is activate...

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Detalles Bibliográficos
Autores principales:	Marasco, Michelangelo, Kirkpatrick, John, Carlomagno, Teresa, Hub, Jochen S., Anselmi, Massimiliano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231330/ https://www.ncbi.nlm.nih.gov/pubmed/37265738 http://dx.doi.org/10.1039/d3sc00746d

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