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Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia

In recent years, network meta-analyses have been increasingly carried out to inform clinical guidelines and policy. This approach is under constant development, and a broad consensus on how to carry out several of its methodological and statistical steps is still lacking. Therefore, different workin...

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Autores principales: Ostuzzi, Giovanni, Schneider-Thoma, Johannes, Tedeschi, Federico, Leucht, Stefan, Barbui, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231437/
https://www.ncbi.nlm.nih.gov/pubmed/37197798
http://dx.doi.org/10.1136/bmjment-2023-300677
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author Ostuzzi, Giovanni
Schneider-Thoma, Johannes
Tedeschi, Federico
Leucht, Stefan
Barbui, Corrado
author_facet Ostuzzi, Giovanni
Schneider-Thoma, Johannes
Tedeschi, Federico
Leucht, Stefan
Barbui, Corrado
author_sort Ostuzzi, Giovanni
collection PubMed
description In recent years, network meta-analyses have been increasingly carried out to inform clinical guidelines and policy. This approach is under constant development, and a broad consensus on how to carry out several of its methodological and statistical steps is still lacking. Therefore, different working groups might often make different methodological choices based on their clinical and research experience, with possible advantages and shortcomings. In this contribution, we will critically assess two network meta-analyses on the topic of pharmacological prevention of relapse in schizophrenia, carried out by two different research groups. We will highlight the implications of different methodological choices on the analysis results and their clinical–epidemiological interpretation. Moreover, we will discuss some of the most relevant technical issues of network meta-analyses for which there is not a broad methodological agreement, including the assessment of transitivity.
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spelling pubmed-102314372023-08-21 Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia Ostuzzi, Giovanni Schneider-Thoma, Johannes Tedeschi, Federico Leucht, Stefan Barbui, Corrado BMJ Ment Health Perspective In recent years, network meta-analyses have been increasingly carried out to inform clinical guidelines and policy. This approach is under constant development, and a broad consensus on how to carry out several of its methodological and statistical steps is still lacking. Therefore, different working groups might often make different methodological choices based on their clinical and research experience, with possible advantages and shortcomings. In this contribution, we will critically assess two network meta-analyses on the topic of pharmacological prevention of relapse in schizophrenia, carried out by two different research groups. We will highlight the implications of different methodological choices on the analysis results and their clinical–epidemiological interpretation. Moreover, we will discuss some of the most relevant technical issues of network meta-analyses for which there is not a broad methodological agreement, including the assessment of transitivity. BMJ Publishing Group 2023-05-17 /pmc/articles/PMC10231437/ /pubmed/37197798 http://dx.doi.org/10.1136/bmjment-2023-300677 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Perspective
Ostuzzi, Giovanni
Schneider-Thoma, Johannes
Tedeschi, Federico
Leucht, Stefan
Barbui, Corrado
Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia
title Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia
title_full Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia
title_fullStr Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia
title_full_unstemmed Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia
title_short Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia
title_sort crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231437/
https://www.ncbi.nlm.nih.gov/pubmed/37197798
http://dx.doi.org/10.1136/bmjment-2023-300677
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