Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report

A woman in her 50’s was diagnosed diffuse large B-cell lymphoma (DLBCL) after presenting to hospital in a critical condition, characterised by marked hyperleukocytosis (white cell count 290 x10(9)/L). She subsequently developed painless blurred vision bilaterally, and was diagnosed with bilateral ce...

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Autores principales: Toohey, Thomas P, Corker, Alma, Lee, Mitchell B, Kidson-Gerber, Giselle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231445/
https://www.ncbi.nlm.nih.gov/pubmed/37265592
http://dx.doi.org/10.2147/IMCRJ.S408404
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author Toohey, Thomas P
Corker, Alma
Lee, Mitchell B
Kidson-Gerber, Giselle
author_facet Toohey, Thomas P
Corker, Alma
Lee, Mitchell B
Kidson-Gerber, Giselle
author_sort Toohey, Thomas P
collection PubMed
description A woman in her 50’s was diagnosed diffuse large B-cell lymphoma (DLBCL) after presenting to hospital in a critical condition, characterised by marked hyperleukocytosis (white cell count 290 x10(9)/L). She subsequently developed painless blurred vision bilaterally, and was diagnosed with bilateral central retinal vein occlusion secondary to leukostasis. She was managed with non-Hodgkin lymphoma R-CHOEP14 (rituximab, cyclophosphamide, doxorubicin, vincristine, etoposide, prednisolone) immunochemotherapy, with her ocular signs and symptoms improving following treatment. Optical coherence tomography and funduscopic examination demonstrated no evidence of intraocular lymphoma. Visual acuity returned to 6/6 in each eye with subsequent resolution of her symptoms. Repeat examination demonstrated stable appearance of her ocular disease.
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spelling pubmed-102314452023-06-01 Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report Toohey, Thomas P Corker, Alma Lee, Mitchell B Kidson-Gerber, Giselle Int Med Case Rep J Case Report A woman in her 50’s was diagnosed diffuse large B-cell lymphoma (DLBCL) after presenting to hospital in a critical condition, characterised by marked hyperleukocytosis (white cell count 290 x10(9)/L). She subsequently developed painless blurred vision bilaterally, and was diagnosed with bilateral central retinal vein occlusion secondary to leukostasis. She was managed with non-Hodgkin lymphoma R-CHOEP14 (rituximab, cyclophosphamide, doxorubicin, vincristine, etoposide, prednisolone) immunochemotherapy, with her ocular signs and symptoms improving following treatment. Optical coherence tomography and funduscopic examination demonstrated no evidence of intraocular lymphoma. Visual acuity returned to 6/6 in each eye with subsequent resolution of her symptoms. Repeat examination demonstrated stable appearance of her ocular disease. Dove 2023-05-27 /pmc/articles/PMC10231445/ /pubmed/37265592 http://dx.doi.org/10.2147/IMCRJ.S408404 Text en © 2023 Toohey et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Toohey, Thomas P
Corker, Alma
Lee, Mitchell B
Kidson-Gerber, Giselle
Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report
title Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report
title_full Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report
title_fullStr Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report
title_full_unstemmed Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report
title_short Bilateral Central Retinal Vein Occlusion Secondary to Leukostasis in the Setting of Diffuse Large-B Cell Lymphoma: Case Report
title_sort bilateral central retinal vein occlusion secondary to leukostasis in the setting of diffuse large-b cell lymphoma: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231445/
https://www.ncbi.nlm.nih.gov/pubmed/37265592
http://dx.doi.org/10.2147/IMCRJ.S408404
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