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Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke
INTRODUCTION: Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological and biological factors. Lesion location is a readily available information in stroke patients, but it is unc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231644/ https://www.ncbi.nlm.nih.gov/pubmed/37265471 http://dx.doi.org/10.3389/fneur.2023.1144228 |
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author | Klingbeil, Julian Brandt, Max-Lennart Stockert, Anika Baum, Petra Hoffmann, Karl-Titus Saur, Dorothee Wawrzyniak, Max |
author_facet | Klingbeil, Julian Brandt, Max-Lennart Stockert, Anika Baum, Petra Hoffmann, Karl-Titus Saur, Dorothee Wawrzyniak, Max |
author_sort | Klingbeil, Julian |
collection | PubMed |
description | INTRODUCTION: Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological and biological factors. Lesion location is a readily available information in stroke patients, but it is unclear if the neurobiological substrates of PSDS are spatially localized. Building on previous analyses, we sought to determine if PSDS are associated with specific lesion locations, structural disconnection and/or localized functional diaschisis. METHODS: In a prospective observational study, we examined 270 patients with first-ever stroke with the Hospital Anxiety and Depression Scale (HADS) around 6 months post-stroke. Based on individual lesion locations and the depression subscale of the HADS we performed support vector regression lesion-symptom mapping, structural-disconnection-symptom mapping and functional lesion network-symptom-mapping, in a reanalysis of this previously published cohort to infer structure–function relationships. RESULTS: We found that depressive symptoms were associated with (i) lesions in the right insula, right putamen, inferior frontal gyrus and right amygdala and (ii) structural disconnection in the right temporal lobe. In contrast, we found no association with localized functional diaschisis. In addition, we were unable to confirm a previously described association between depressive symptom load and a network damage score derived from functional disconnection maps. DISCUSSION: Based on our results, and other recent lesion studies, we see growing evidence for a prominent role of right frontostriatal brain circuits in PSDS. |
format | Online Article Text |
id | pubmed-10231644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102316442023-06-01 Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke Klingbeil, Julian Brandt, Max-Lennart Stockert, Anika Baum, Petra Hoffmann, Karl-Titus Saur, Dorothee Wawrzyniak, Max Front Neurol Neurology INTRODUCTION: Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological and biological factors. Lesion location is a readily available information in stroke patients, but it is unclear if the neurobiological substrates of PSDS are spatially localized. Building on previous analyses, we sought to determine if PSDS are associated with specific lesion locations, structural disconnection and/or localized functional diaschisis. METHODS: In a prospective observational study, we examined 270 patients with first-ever stroke with the Hospital Anxiety and Depression Scale (HADS) around 6 months post-stroke. Based on individual lesion locations and the depression subscale of the HADS we performed support vector regression lesion-symptom mapping, structural-disconnection-symptom mapping and functional lesion network-symptom-mapping, in a reanalysis of this previously published cohort to infer structure–function relationships. RESULTS: We found that depressive symptoms were associated with (i) lesions in the right insula, right putamen, inferior frontal gyrus and right amygdala and (ii) structural disconnection in the right temporal lobe. In contrast, we found no association with localized functional diaschisis. In addition, we were unable to confirm a previously described association between depressive symptom load and a network damage score derived from functional disconnection maps. DISCUSSION: Based on our results, and other recent lesion studies, we see growing evidence for a prominent role of right frontostriatal brain circuits in PSDS. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10231644/ /pubmed/37265471 http://dx.doi.org/10.3389/fneur.2023.1144228 Text en Copyright © 2023 Klingbeil, Brandt, Stockert, Baum, Hoffmann, Saur and Wawrzyniak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Klingbeil, Julian Brandt, Max-Lennart Stockert, Anika Baum, Petra Hoffmann, Karl-Titus Saur, Dorothee Wawrzyniak, Max Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke |
title | Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke |
title_full | Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke |
title_fullStr | Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke |
title_full_unstemmed | Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke |
title_short | Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke |
title_sort | associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231644/ https://www.ncbi.nlm.nih.gov/pubmed/37265471 http://dx.doi.org/10.3389/fneur.2023.1144228 |
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