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Binding pocket dynamics along the recovery stroke of human β-cardiac myosin
The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins. The breakthrough discovery of omecamtiv mecarbil (OM) has led t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231807/ https://www.ncbi.nlm.nih.gov/pubmed/37200380 http://dx.doi.org/10.1371/journal.pcbi.1011099 |