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Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core

The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprotein subunit and contains a central coiled coil that...

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Detalles Bibliográficos
Autores principales:	Poumbourios, Pantelis, Langer, Christine, Boo, Irene, Zakir, Tasnim, Center, Rob J., Akerman, Anouschka, Milogiannakis, Vanessa, Aggarwal, Anupriya, Johnstone, Bronte A., Ha, Jungmin, Coulibaly, Fasséli, Turville, Stuart G., Drummer, Heidi E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231827/ https://www.ncbi.nlm.nih.gov/pubmed/37200378 http://dx.doi.org/10.1371/journal.ppat.1010981

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