ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease

Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase (TS) antigens either in the form of recombinant protein, encoded in plasmids or human adenovirus 5 (hAd5) confers robust protection against various lineages of Trypanosoma cruzi. Herein we generated a chimeric protein con...

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Detalles Bibliográficos
Autores principales: Castro, Julia T., Brito, Rory, Hojo-Souza, Natalia S., Azevedo, Bárbara, Salazar, Natalia, Ferreira, Camila P., Junqueira, Caroline, Fernandes, Ana Paula, Vasconcellos, Ronnie, Cardoso, Jamille M., Aguiar-Soares, Rodrigo D. O., Vieira, Paula M. A., Carneiro, Cláudia M., Valiate, Bruno, Toledo, Cristiane, Salazar, Andres M., Caballero, Otávia, Lannes-Vieira, Joseli, Teixeira, Santuza R., Reis, Alexandre B., Gazzinelli, Ricardo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231858/
https://www.ncbi.nlm.nih.gov/pubmed/37258518
http://dx.doi.org/10.1038/s41541-023-00676-0

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