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Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection
Clostridioides difficile (C. difficile)and coronavirus disease 2019 (COVID-19) infections can have overlapping symptoms. Recently, the association and outcomes of coinfection have been studied. We present the case of an 83-year-old lady with Parkinson’s disease (PD) who was admitted with pneumonia s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231867/ https://www.ncbi.nlm.nih.gov/pubmed/37265903 http://dx.doi.org/10.7759/cureus.38401 |
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author | Duhan, Sanchit Keisham, Bijeta Salim, Ahlaa |
author_facet | Duhan, Sanchit Keisham, Bijeta Salim, Ahlaa |
author_sort | Duhan, Sanchit |
collection | PubMed |
description | Clostridioides difficile (C. difficile)and coronavirus disease 2019 (COVID-19) infections can have overlapping symptoms. Recently, the association and outcomes of coinfection have been studied. We present the case of an 83-year-old lady with Parkinson’s disease (PD) who was admitted with pneumonia secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. She was treated with empiric antibiotics ampicillin-sulbactam and azithromycin, along with antiviral therapy remdesivir and baricitinib, and dexamethasone. The patient developed severe C. difficile infection with a leukemoid reaction. She was treated with intravenous metronidazole and oral vancomycin without any improvement. Before she could receive a fecal microbiota transplant, her infection progressed to fulminant colitis, and she required emergent surgery. The patient developed several complications post-surgery and succumbed to the severe illness. Our patient’s multiple comorbidities and an underlying COVID-19 infection predisposed her to severe illness. This case emphasizes the long-standing discussion on antibiotic stewardship and encourages a debate on the role of immunosuppressant antiviral medications and underlying PD in predisposing patients to a severe C. difficile infection. |
format | Online Article Text |
id | pubmed-10231867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-102318672023-06-01 Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection Duhan, Sanchit Keisham, Bijeta Salim, Ahlaa Cureus Internal Medicine Clostridioides difficile (C. difficile)and coronavirus disease 2019 (COVID-19) infections can have overlapping symptoms. Recently, the association and outcomes of coinfection have been studied. We present the case of an 83-year-old lady with Parkinson’s disease (PD) who was admitted with pneumonia secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. She was treated with empiric antibiotics ampicillin-sulbactam and azithromycin, along with antiviral therapy remdesivir and baricitinib, and dexamethasone. The patient developed severe C. difficile infection with a leukemoid reaction. She was treated with intravenous metronidazole and oral vancomycin without any improvement. Before she could receive a fecal microbiota transplant, her infection progressed to fulminant colitis, and she required emergent surgery. The patient developed several complications post-surgery and succumbed to the severe illness. Our patient’s multiple comorbidities and an underlying COVID-19 infection predisposed her to severe illness. This case emphasizes the long-standing discussion on antibiotic stewardship and encourages a debate on the role of immunosuppressant antiviral medications and underlying PD in predisposing patients to a severe C. difficile infection. Cureus 2023-05-01 /pmc/articles/PMC10231867/ /pubmed/37265903 http://dx.doi.org/10.7759/cureus.38401 Text en Copyright © 2023, Duhan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Duhan, Sanchit Keisham, Bijeta Salim, Ahlaa Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection |
title | Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection |
title_full | Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection |
title_fullStr | Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection |
title_full_unstemmed | Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection |
title_short | Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection |
title_sort | fulminant clostridioides difficile colitis with sars-cov-2 infection |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231867/ https://www.ncbi.nlm.nih.gov/pubmed/37265903 http://dx.doi.org/10.7759/cureus.38401 |
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