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Protein-mediated interactions in the dynamic regulation of acute inflammation
Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231872/ https://www.ncbi.nlm.nih.gov/pubmed/37261220 http://dx.doi.org/10.32604/biocell.2023.027838 |
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author | STARK, RYAN |
author_facet | STARK, RYAN |
author_sort | STARK, RYAN |
collection | PubMed |
description | Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important molecules as well. These proteins are often involved in multibody complexes that work dynamically to regulate cellular health and function. Various techniques have been adapted to study these important interactions, such as affinity-based assays, mass spectrometry, and fluorescent detection. The application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory diseases. These pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation. |
format | Online Article Text |
id | pubmed-10231872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-102318722023-05-31 Protein-mediated interactions in the dynamic regulation of acute inflammation STARK, RYAN Biocell Article Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important molecules as well. These proteins are often involved in multibody complexes that work dynamically to regulate cellular health and function. Various techniques have been adapted to study these important interactions, such as affinity-based assays, mass spectrometry, and fluorescent detection. The application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory diseases. These pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation. 2023 2023-05-19 /pmc/articles/PMC10231872/ /pubmed/37261220 http://dx.doi.org/10.32604/biocell.2023.027838 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article STARK, RYAN Protein-mediated interactions in the dynamic regulation of acute inflammation |
title | Protein-mediated interactions in the dynamic regulation of acute inflammation |
title_full | Protein-mediated interactions in the dynamic regulation of acute inflammation |
title_fullStr | Protein-mediated interactions in the dynamic regulation of acute inflammation |
title_full_unstemmed | Protein-mediated interactions in the dynamic regulation of acute inflammation |
title_short | Protein-mediated interactions in the dynamic regulation of acute inflammation |
title_sort | protein-mediated interactions in the dynamic regulation of acute inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231872/ https://www.ncbi.nlm.nih.gov/pubmed/37261220 http://dx.doi.org/10.32604/biocell.2023.027838 |
work_keys_str_mv | AT starkryan proteinmediatedinteractionsinthedynamicregulationofacuteinflammation |